(IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the...
(IC50 = 483 nM in rat brain synaptic membranes). Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the...
When used to treat disorders of gastric motility and esophageal reflux, metoclopramide should be administered at a dose of 0.2–0.5 mg/kg PO 30 min before meals. Pharmacokinetics Metoclopramide is well absorbed from the gastrointestinal tract in humans and dogs. In humans, bio-availability can be...
Metoclopramideis well absorbed from the gastrointestinal tract in humans and dogs. In humans, bio-availability can be reduced by up to 30% in some patients as a result of first-pass metabolism; this effect is quite variable among individuals. One study suggested that similarly, in dogs, the ...
DogsHumansMetoclopramideInjections, IntravenousSpecies SpecificityBiological AvailabilityKineticsHalf-LifeAdult1 The pharmacokinetics of metoclopramide have been studied in eight normal male volunteers. 2 The mean plasma beta half-life was 156.7 min after i.v. administration of 10 mg metoclopramide. 3 After...
16094) in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively. Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM for competitive and non-competitive inhibition, respectively). Formulations containing ...
In vivo evaluation of sustained-release microspheres of metoclopramide hydrochloride in beagle dogs The in vivo absorption characteristics of metoclopramide hydrochloride microspheres prepared from cellulose propionate polymer by an emulsion-solvent evapo... YM El-Sayed,EM Niazy,SH Khidr - 《International ...
(300mg, iv). The effects of metoclopramide seem to be independent of either the type of anaesthetic or the premedicant used but for optimum effect may need to be given towards the end of the operation. Controlled trials have demonstrated that 10mg intramuscular metoclopramide is significantly ...
Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs Maropitant (Cerenia™; a novel, selective neurokinin1 receptor antagonist), chlorpromazine, metoclopramide and ondansetron were compared in two randomize... HS Sedlacek...
2 Oral administration of metoclopramide inhibits emesis induced by cisplatin and apomorphine in ferrets and dogs with ED50 values of 6.17 and 0.45 mg/kg, respectively.1,2 Metoclopramide reversibly inhibits human acetylcholinesterase (AChE) isolated from the caudate nucleus (Kis = 9.3 and 82 μM ...