Cmax (ng/mL) is 13.61 (42.56), Tmax (hr) is 5.00 (1.67-6.00) and T1/2 (hr) is 5.65 (15.01) at a dose equivalent to about 60 mg racemic methylphenidate hydrochloride in
activated microglia in the SNpc….Unbiased gene screening employing Affymetrix GeneChip® HT MG-430 PM revealedchanges in 115 and 54 genes in the substantia nigra (SN) of miceexposed to 1 mg/kg and 10 mg/kg MPH doses, respectively. ..We also found an increase in mRNA levels of the p...