B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several studies have linked differential methylation to self-reported intakes of folate and B12, but these estimates can be imprecise, while metabolomic biomarkers can...
we deleted these exons in NE-4C cells (leavingmiR124asequence intact; Fig.1b; Supplementary Fig.2d). Exons 2/3 deletion notably reduced NEPC proliferation and survival (Fig.1e). To comprehensively evaluate the effects of full-lengthRncr3–miR124aKO and exons 2/3 deletion, ...
LncRNAs can alter translation of protein-coding genes without affecting mRNA levels, for example, by formation of a ribonucleoprotein complex with RNA-binding proteins, as shown for the regulation of E-cadherin by translational regulatory lncRNA (treRNA) with tumor- and metastasis-promoting properties...