4.2.6. Methyl 3-(3-methoxyphenyl)propiolate (3l) Yellow liquid. 1H NMR (400 MHz, CDCl3): δ 7.20 (t, J = 8.0 Hz, 1H), 7.10 (d, J = 7.6 Hz, 1H), 7.01 (s, 1H), 6.92 (dd, J = 8.0, 2.0 Hz, 1H), 3.76 (s, 3H), 3.72 (s, 3H...
2.7. Butyl 3-(4-methoxyphenyl)propiolate (2e) [25] 1H NMR (CDCl3, 500 MHz) δ (ppm): 7.54 (d, J = 9.0 Hz, 2H), 6.88 (d, J = 9.0 Hz, 2H), 4.23 (t, J = 6.5 Hz, 2H), 3.83 (s, 3H), 1.72–1.66 (m, 2H),1.46–1.40 (m, 2H), 0.96 (t, J = 7.5 Hz, 3H); ...
The three-component reaction of 4-phenyl-, p -methoxyphenyl-, and thienylpyrrolo[1,2- a ][1,4]benzo-diazepines with methyl propiolate and indole in dichloromethane proceeds through opening of the diazepine ring. The major transformation products isolated are substituted pyrroles, namely, 1-(2-...
2-3. (canceled) 4. A method of inhibiting MRP1 which comprises administering to a mammal in need thereof an effective amount of a compound of claim 1. 5-7. (canceled) 8. A method of inhibiting a resistant neoplasm, or a neoplasm susceptible to resistance, in a mammal which compris...
However, p-anisoylphenylacetylene gave a mixture of (Z)- and (E)-3-(methoxycarbonylmethylthio)-1-(p-methoxyphenyl)-3-phenyl-2-propen-1-ones in the ratio of 4:1. This ratio was completely inverted when the latter addition was carried out in dry benzene. Rationalisation of these results ...