Second, the O-TMS group protects the acyloin (see Section 3.1.2), allowing further manipulation prior to unmasking the relatively sensitive α-hydroxyketone moiety. When there are no enolizable hydrogen atoms in the O-TMS derivative, treatment with bromine generates a 1,2-diketone.208 When eno...
((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-fluoro-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methyl diphenyl phosphate; isopropyl ((S)-(((2S,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-fluoro-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phospho...