Mixed methods researchSpeaking/oral proficiency assessmentIt is not surprising that there are continuing tensions between the disciplinary research paradigms in which language testers situate themselves: psycho
SARS-CoV-2入侵通常依赖于病毒尖峰蛋白与宿主ACE2之间的结合,以及尖峰蛋白在内源性蛋白酶的作用。然而,完整的入侵过程既直接又间接地依赖于数百个宿主基因网络,这个网络仍然不为人们所了解。 高通量功能基因筛选主要使用CRISPR-Cas9系统进行敲除(CRISPR-KO)和激活(CRISPRa)格式的筛选,这为识别促进病毒入侵的宿主基因提...
Product researchis the process of gathering information about a product idea, target market, and existing competitors. It helps you analyze whether there’s demand for your product and if it meets customer needs, and identify potential challenges before investing in development. For new entrepreneurs,...
Springer Nature is proud to announce ‘Methods Muse’, a new platform supporting experimental work by streamlining protocol design, implementation, validation, and optimization. Integrated withprotocols.io,Methods Muse offers prompt-based protocol generation and troubleshooting, thus saving valuable time, ef...
Deep learning-assisted analysis of single-particle tracking for automated correlation between diffusion and function DeepSPT is a deep learning framework for the automated temporal analysis of behavior in 2D and 3D single-particle tracking. After extensive validation, DeepSPT was shown to work on diver...
in visualization mode with real-time visualization of the preprocessed images to optimize analysis pipeline parameters; or in validation mode without triggering scans. While running etSTED experiments, detected event coordinates will be overlaid on the displayed widefield frames. The triggered imaging wil...
Methodspublishes original review and research articles that cover emerging methodology in many areas of life and health sciences. The research areas covered byMethodsinclude, but are not limited to, • Biochemistry and biophysics • Cell, molecular, and developmental biology and genetics ...
Revolutionizing cancer research with spatial proteomics and visual intelligence Molecular motion in situ More dimensions of the 3D genome Organoids get an upgrade Biomechanical modeling of whole bodies Mapping cell history and fates Subcellular spatial proteomics ...
DOME: recommendations for supervised machine learning validation in biology DOME is a set of community-wide recommendations for reporting supervised machine learning–based analyses applied to biological studies. Broad adoption of these recommendations will help improve machine learning assessment and reproducib...
The same assumption is also needed for traditional PRS analyses based on an independent validation dataset to tune parameters. If the validation and testing datasets are heterogeneous, the AUC estimated from the validation dataset and the parameter selected based on the estimated results are not ...