Animals receive the test compound once a day for 5 days. Thereafter, they are sacrificed, spleens are removed, and a single cell suspension of 5 × 106cells/ml is prepared. Mitogens are titrated (four replicates/group) in 0.1 ml/well and 0.1 ml of the cell suspension is added. Pl...
Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective chapters, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. ...
Finally, small molecule IRE1α RNase inhibitors suppress TXNIP production to block IL-1β secretion. In summary, the IRE1α-TXNIP pathway is used in... Alana G.,Lerner,John-Paul,... - 《Cell Metabolism》 被引量: 519发表: 2012年 Recent Progress in the Design of Small Molecule Inhibitors...
The methods of making and using thereof, as well as pharmaceutical formulations useful for inhibiting acid secretionBioavailability include antacids one, improved and at least acid-labile proton pump inhibitor with at least one chemical stability, physical stability, dissolution profiles, the present ...
This is likely an active enzymatic process happening in the neurons prior to or during secretion. Hence, targeting N-terminal tau is easier in biofluids than targeting full-length or C-terminal tau. However, there are also emerging data that C-terminal tau, measured using very sensitive assays...
Plant cells usually sustain a stable membrane potential due to influx and/or efflux of charged ions across plasma membrane. With the growth and development of plants, different tissues and cells undergo systemic or local programmed decline. Whether the m
Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure Enteropathogenic Escherichia coli (EPEC) secretes several Esp proteins via the type III secretion system (secreton). EspA, EspB, and EspD are ...
2006. Insulin secretion by anthocyanins and anthocyanidins. US Patent and Trademark Office, United States Patent Application No:20060025353. Nepokroeff M, Sytsma KJ, Wagner WL, Zimmer EA. 2003. Reconstructing ancestral patterns of colonization and dispersal in the Hawaiian understory tree genus ...
High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay. Cell Rep. Methods 2, 100267 (2022). Article CAS PubMed PubMed Central Google Scholar Verweij, F. J. et al. Live tracking of inter-organ communication by endogenous exosomes in vivo...
7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B This invention relates to compounds of Formula I that inhibit the secretion of apolipoprotein B, to pharmaceutical compositions comprising the compounds, and...