The present invention relates to triaminopyrimidines and to pharmaceutically acceptable salts thereof, to their use in the treatment and or prevention of malaria caused by plasmodium species, and to their methods of preparation.HAMEED PEER MOHAMED, SHAHUL...
In this method, an ethanolic solution containing phospholipids is prepared and, then, it is injected into a large volume of water or phosphate buffer; in this way, phospholipids tend to arrange in a bi-layer fragment. After the precipitation of these fragments in the aqueous phase, they tend ...
Malaria is a major cause of global morbidity and mortality, and new strategies for treating and preventing this disease are needed. Here we show that the Streptococcus pyogenes Cas9 DNA endonuclease and single guide RNAs (sgRNAs) produced using T7 RNA polymerase (T7 RNAP) efficiently edit the...
Table6below summarises the key themes drawn through the inductive and deductive methods emerging from the study: the fidelity of HI implementation by the local community, the feasibility of HI implementation by the community, and the sustainability of HI as an intervention for preventing malaria. ...
as shown in Fig.5f17. The 3D reconstruction information can greatly improve the operation accuracy while reducing the damage to biological objects. Specifically, the success rate of mitochondrial extraction experiments is 20% higher than that of traditional 2D methods, preventing the cell destruction ...
The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. In particular embodiments, a composition comprises mosquito nectar feed and Chromobacteriu...
treatment of a number of other diseases such as cancer, malaria and bacterial infections; however they have not been used for the treatment of these ... V Aalten,MF D. - 《Biochimica Et Biophysica Acta》 被引量: 93发表: 2002年 Synthesis of 5'-Methylthio Coformycins: Specific Inhibitors...
METHODS AND COMPOUNDS FOR TREATING MALARIAA pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need ...
Pre-erythrocytic antigens, which are expressed in the sporozoite and liver stages of thePlasmodiumspp. life cycle, are particularly promising targets for malaria vaccine development, with great potential to prevent infection and transmission. The pre-erythrocytic stages of the parasitic life cycle are ...
The invention is directed to immunogenic compositions, and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents. In particular, the invention provides immunogenic compositions and methods for preventing, treating, and/or ameliorating microbial infecti...