Methamphetamine (METH) is a highly addictive amphetamine-type drug that has caused persistent harm to society and human health in recent years. Most studies have shown that METH severely damages the central nervous system, and this drug has been found to be toxic to the cardiovascular system in...
Since methamphetamine and other amphetamine-type stimulants (meth/amphetamine) can damage dopaminergic neurons, researchers have long speculated that these... RC Callaghan,JK Cunningham,J Sykes,... - 《Drug & Alcohol Dependence》 被引量: 192发表: 2012年 Abuse of Amphetamines and Structural Abnormali...
HIV infection and drug use intersect epidemiologically, and their combination can result in complex effects on brain and behavior. The extent to which drugs affect the health of persons with HIV (PWH) depends on many factors including drug characteristics, use patterns, stage of HIV disease and i...
(–CH3) and the addition of a second methyl group in the basic nitrogen leads to METH. Alterations to the benzene ring yieldmethylenedioxymethamphetamine(MDMA), most commonly known as “ecstasy,” andmethylenedioxyamphetamine(MDA), also known as the love drug or Eva (Fig. 57.1). Another ...
Meth significantly increased proceptive behaviors in hormonally primed wild type and cFos-lacZ transgenic rats compared to those treated with EB + P alone. A two-way ANOVA with drug and genetic strain as factors revealed a significant main effect of Meth (F(1,12) = 61.99, p <...
Repeated exposure to methamphetamine (METH) can cause not only neurotoxicity but also addiction. Behavioral sensitization is widely used as an animal model for the study of drug addiction. We previously reported that the μ-opioid receptor knockout mice
Increased risk of Parkinson’s disease in individuals hospitalized with conditions related to the use of methamphetamine or other amphetamine-type drugs. Drug Alcohol Depend. 2012;120(1-3):35-40.PubMedGoogle ScholarCrossref 88. Curtin K, Fleckenstein AE, Robison RJ, Crookston MJ, Smith KR, ...
Despite the effectiveness of psychosocial programs for recovery from drug use problems, there have been challenges in implementation of treatment. Internet-based and computerized approaches have been known to be effective in treatment dissemination. The study purpose is to assess the effects of a web-...
The most promising approach for investigating illegal synthetic drugs may be the study of drug precursors and how the precursors’ isotopic signals are maintained or modified during the production process. Pseudoephedrine, a direct precursor to methamphetamine, is largely produced by the fermentation of ...
1A). However, the functional link between proline and glutamate during drug exposure induced glutamate neurotransmission is poorly understood. Therefore, we examined the effects of METH exposure on proline metabolism using the SH-SY5Y neuronal cell model. First, we measured the levels of enzymes of...