Table1shows the usually accepted diagnostic criteria for the diagnosis of prediabetes based on measurements of glycaemia [4,8–10]. A simple blood test is sufficient to diagnose IFG, while a 75 g oral glucose tolerance test (OGTT) is required for the diagnosis of IGT. The originally used c...
Metformin therapy was found to be safe for use in individuals with HIV and prediabetes. A larger trial with longer follow up is needed to establish if metformin can be safely used for the prevention of diabetes in people who have HIV.Trial registration The trial is registered on the ...
Diabetes mellitusmetforminprostate cancersurvivalhazard ratiosObjective To assess prostate cancer-specific and overall survival in prostate cancer patients with or without preexisting type 2 diabetes mellitus (T2DM) with regards to metformin use. Methods Patients diagnosed with prostate cancer in the ...
Metformin use was low even among those with BMI ≥35 kg/m2, a group for whom metformin use is recommended. Metformin use did not vary by race, poverty-to-income ratio, or education.CONCLUSIONSMetformin use was <1% among U.S. adults with prediabetes and only slightly more common among ...
Guanidine derivatives, including metformin, were synthesised and some (not metformin) were used to treat diabetes in the 1920s and 1930s but were discontinued due to toxicity and the increased availability of insulin. Metformin was rediscovered in the search for antimalarial agents in the 1940s ...
Metformin also shows properties in treating aberrant glucose utilization-related metabolic disorders, including prediabetes, polycystic ovary syndrome, and obesity [5–7]. In addition, accumulating evidence have shown metformin potentially showed improvements in the non-fatty alcoholic liver, anti-tumor, ...
of patients with type 2 diabetes and describe the additional benefits beyond its glycemic effect. We also discuss its potential role for a variety of insulin resistant and pre-diabetic states, obesity, metabolic abnormalities associated with HIV disease, gestational diabetes, cancer, and neuroprotection...
Exosomes derived from tumor cells contribute to the pathogenesis of cancers. Metformin, the most usually used drug for type 2 diabetes, has been frequently investigated for anticancer effects. Here, we examined whether metformin affects exosomes signalin
Some studies found negative or neutral effects for metformin use by people with diabetes; the potential mechanism of metformin-induced vitamin B12 deficiency is discussed. Conclusions: Metformin should continue to be used as a first line therapy for diabetes in patients at risk of developing dementia...
Should Metformin Be First-Line Therapy for Patients With Type 2 Diabetes and Chronic Kidney Disease?: Informed Patients Should Decide There are now 11 drug classes in addition to multiple insulin options from which to choose to treat patients presenting with new-onset type 2 diabetes (T2D... CB...