been given to the repurposing of metformin as part of adjunct therapy for the treatment of cancer, age-related diseases, inflammatory diseases and COVID-19. In this Review, we highlight the latest advances in our understanding of the mechanisms of action of metformin and discuss potential emergin...
Metformin: update on mechanisms of action on liver diseasesdoi:10.3389/fnut.2023.1327814Gaoyi RuanFangquan WuDibang ShiHongxia SunFangyan WangChanglong XuFrontiers in Nutrition
The knowledge gained from dissecting the principal mechanisms by which metformin works can help us to develop novel treatments. The centre of metformin's mechanism of action is the alteration of the energy metabolism of the cell. Metformin exerts its prevailing, glucose-lowering effect by inhibiting...
6.19.6.4.3.2Mechanisms of action The specific mechanisms of action ofmetforminhave not been definitively demonstrated. In the liver, metformin increases insulin-dependent suppression ofgluconeogenesisand decreases the glucagon-dependent stimulation of gluconeogenesis, resulting in an overall decrease in hepatic...
Metformin: from mechanisms of action to therapies. Cell Metab. 20, 953–966 (2014). 9. Akhurst, R. J. & Hata, A. Targeting the TGFbeta signalling pathway in disease. Nat Rev Drug Discov. 11, 790–811 (2012). 10. Duvnjak, M. et al. Therapy of nonalcoholic fatty liver disease: ...
It has been proposed that the can- cer preventive actions of metformin involve four compo- nents: 1) cancer stems cells, 2) microRNAs (miRs), 3) epithelial-to-mesenchymal transition (EMT), and 4) cel- lular senescence [9, 11, 12]. But as with diabetes, details of the mechanisms by...
The impact of metformin on weight loss is attributed to its appetite-suppressing properties, although the mechanisms involved are still unclear. Metformin-induced increases in the hormone GDF15 were proposed to mediate appetite suppression11,12, but recent findings have challenged whether this is the ...
Metformin: Mechanisms of antihyperglycemic action, other pharmacodynamic properties, and safety perspectives To characterize the mechanisms of action of metformin and describe its effects and safety profile. Results of more than 30 years of clinical use in countries other than the United States are summa...
of subtypes [35,36]. Hence, the mechanisms of action of metformin must be closely related to the hallmarks of cancer [37], which have been proposed as a common set of functional capabilities crucial to the transformation from normalcy to malignancy. This review focused on the effects of ...
This was accompanied by a sharp decrease in the expression of c-Myc and down-regulation of IGF1R. The anti-proliferative action of metformin was mediated by two different mechanisms: AMPK activation and increase in the production of reactive oxygen species, which suppressed the mTOR pathway and ...