Metformin and vitamin B12 deficiencyWainwright, PatrickDiabetes & Primary CareGilligan MA. Metformin and vitamin B12 deficiency. Arch Intern Med 162: 484-485, 2002.
After six months of rehabilitation, he could walk independently with a stick but there was persistent lower-limb ataxia and sensory deficits (with residual high T2 signal). This patient had multiple risk factors for developing B12 deficiency: vegetarianism, age, diabetes mellitus and Metformin use....
The majority of the women had not had their B12levels measured. However, upon testing, almost 1 in 10 were found to have a B12deficiency. Although metformin is recommended for the first-line treatment of type 2 diabetes, it is associated with vitamin B12deficiency, which itself increases the ...
We report two cases who had symptomatic vitamin B12 deficiency related to metformin use; the mechanisms are discussed. The clinician must be aware of the possibility of metformin-associated B12 deficiency in users who suffer cognitive impairment, peripheral neuropathy, subacute combined degeneration of ...
Metformin: Vitamin B12 deficiency and peripheral neuropathy: case report
Our companion article outlines how metformin use can lead to a clinically significant deficiency in vitamin B12, and describes the problems this can cause. In this comment, we outline a project conducted in four primary care practices that aimed to improve metformin-relat...
There was no correlation between the duration of Metformin use and the vitamin B12 level. Likewise there was no correlation observed in the MCV level and vitamin B12 deficiency states. However, PN was documented in 7% of the normal, 23% in low normal and 77% in defiency...
Metformin use is associated with a vitamin B12 deficiency. The influence of both duration and dose of metformin use on vitamin B12 deficiency is unclear. Mostly total vitamin B12 is used as a marker for vitamin B12 deficiencydoi:10.1007/s12467-014-0053-yHart, Huberta E....
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Vit B12 (pg/mL) 299.64 ± 41.75 301.72 ± 40.90 p = 0.307 295.06 ± 35.4 288.27 ± 34.66 p = 0.107 p = 0.092 Data presented as mean ± SD, Bonferroni adjusted (0.05 / 18) TNF-α, tumor necrosis factor alpha; IL-1β, interleukin-1 beta; IL-6, interleukin-6; IGF-1, insulin-li...