For this preplanned group of 38 patients, oral administration of LCE more than doubled life expectancy, 26.3 months for LCE compared to 12.6 months for placebo, with a convincing p value= 0.02. For the first time ever, a group of patients with metastatic RCC refractory to the standard ...
Inclusion criteria were histologically-proven metastatic RCC of any histologic subtype, patient should not be suitable for immunotherapy, measurable disease (at least one lesion 1 cm in diameter) where the only assessable disease is bone metastasis and the lesions must be visible on plain x-ray or...
Health-Related Quality of Life ORR: Overall response rate OS: Overall survival PF: Physical Functioning PFS: Progression-free survival PRO: Patient-reported outcome QL: Global Quality of Life QLQ-C30: Quality of Life Core Questionnaire RCC: Renal cell carcinoma REMOQOL: Routine Electr...
The status of molecular therapeutics for melanoma, NSCLC and RCC is of particular interest for spine surgeons. Patients with these primary tumor types have historically demonstrated poor survival due to poorly controlled systemic disease and radio resistance. For hormone sensitive tumors, specifically brea...
Renal cell carcinoma (RCC) accounts for 3% of all malignancies worldwide and has the highest prevalence in Western countries [1], [2]. The more frequent use of cross-sectional imaging has resulted in an approximate 2% annual increase in the incidence of RCC per year, although this does not...
in combination with axitinib for the first-line treatment of patients with medium to high risk unresectable or metastatic renal cell carcinoma (RCC); in combination with etoposide plus platinum for the first-line treatment of extensive-sta...
Methods: This is a prospective nonrandomized, single-centre, observational study. Consecutive consenting adult (age>18 years) patients with biopsy-proven metastatic clear cell RCC (ccRCC) planned for targeted first and second-line TKI with a life expectancy of more than 6 months were recruited to...
Results: Elderly patients categorized as favorable risk group based on the International Metastatic RCC Database Consortium (IMDC) stratification system were significantly lower. Among IMDC risk factors, the rate of anemia was significantly higher in elderly patients. No statistically significant benefit ...
We also performed subgroup analyses according to systemic therapy (ST) type and Memorial Sloan Kettering Cancer Center (MSKCC)/International Metastatic RCC Database Consortium (IMDC) risk scores. We assessed the risk of bias using the Risk of Bias in Non-randomized Studies of Interventions and ...
Received: 27 February 2020; Accepted: 30 March 2020; Published: 31 March 2020 Abstract: Clear cell renal cell carcinoma (ccRCC) is the main type of RCC, which is the most common type of malignant kidney tumor in adults. A subpopulation (>30%) of ccRCC patients develop metastasis; however...