Although metastatic breast cancer remains incurable, increases in disease-free and overall survival has been achieved. Recent advances in the biological targeted therapies against Her2/ neu, VEGF, and EGFR are now either approved therapies or are in the final stages of clinical testing. Oncology ...
The staging system was developed using data from 42,467 patients from the National Cancer Database (NCDB) who had metastatic breast cancer at the time of their initial diagnosis in 2010 to 2016. Recursive partitioning analysis was used to categorize patients with similar overall survival on the...
In one example, bulk RNA-sequencing (RNA-seq) revealed novel molecular pathways and differentially expressed genes (DEGs) associated with distinct stages of breast cancer progression [7]. However, traditional profiling studies are complicated by the underlying heterogeneity of cancer progression. The ...
Metastasis is the main cause of death for patients with breast cancer. Many studies have characterized the genomic landscape of breast cancer during its early stages. However, there is evidence that genomic alterations are acquired during the evolution of cancers from their early to late stages, an...
Breast Cancer - Targets and Therapy Dovepress open access to scientific and medical research Open Access Full Text Article Clinic al Trial Report Efficacy and tolerability of BP-C1 in metastatic breast cancer: a Phase II, randomized, double-blind, and placebo-controlled Thai multi-center study ...
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the ...
Numerous imaging modalities may be used for the staging of women with advanced breast cancer. Although bone scintigraphy and multiplanar-CT are the most frequently used tests, others including PET, MRI and hybrid scans are also utilised, with no specific
Silberfarb PMMaurer LHCrouthamel CS Psychosocial aspects of neoplastic disease, I: functional status of breast cancer patients during different treatment regimens. Am J Psychiatry. 1980;137450- 455Google Scholar 10. Gotay CC The experience of cancer during early and advanced stages: the views of ...
Although extensive whole-genome analyses of primary or metastatic tumour types have been conducted4,5, large-scale comparative studies between the two tumour stages remain limited due to the logistical challenges associated with obtaining pan-cancer cohorts of primary and metastatic cancers. To circumvent...
aAdjuvant treatment in early-stage metastatic breast cancer models used in (b–h). Following tumor removal (2w post-inoculation), mice received two cycles of chemotherapy, or PBS as control.bIncidence of lung macro-metastases at early stages;n = 27, 28, and 16 mice in control, doxorub...