Limiting concentrations of these factors select for cancer cells with high Src activity, a known clinical predictor of bone relapse and an enhancer of PI3K-Akt pathway activation by CXCL12 and IGF1. Carcinoma clones selected in this manner are primed for metastasis in the CXCL12-rich ...
Peritoneal metastases usually originate from intra-abdominal cancers such as gastrointestinal or ovarian cancer, and are caused by exfoliation of cancer cells causing numerous small cancer implants on the peritoneal surfaces throughout the abdominal cavity. ...
A recent study implicates lysyl oxidase (LOX) as a HIF-1 target that mediates metastasis of human breast cancer cells in a mouse model and correlates with poor overall survival among estrogen receptor-negative breast cancer patients (Erler et al., 2006). LOX is required for the maturation of...
teasing the possibility of a new breakthrough. Cure for cancer post-metastases still seems tantalisingly out of reach. Once metastasized, cancer-related death is extremely difficult, if not
Regarding the propensity of extrinsic tumors to metastasize to the liver, as early as 1889, Stephen Paget proposed the “Seeds and Soil” hypothesis. This hypothesis suggests that the affinity of tumors for the microenvironment can determine the site of metastasis [11]. Cancer cells, much like ...
Khoshbakht S, Azimzadeh Jamalkandi S, Masudi-Nejad A. Involvement of immune system and epithelial–mesenchymal-transition in increased invasiveness of clustered circulatory tumor cells in breast cancer. BMC Med Genomics. 2021. https://doi.org/10.1186/s12920-021-01112-9. Article PubMed PubMed Cen...
Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell...
Lymph node metastases from solid cancers are a frequent occurrence in extensive metastatic dissemination due to the propensity of cancer cells to spread through the lymphatic drainage, often determining in-transit metastases [6]. However, in case of limited or isolated metastatic lymph-node involvement...
An approach that facilitates rapid isolation and characterization of tumor cells with enhanced metastatic potential is highly desirable. Here, we demonstrate that plating GI-101A human breast cancer cells on hard (0.9%) agar selects for the subpopulation of metastasis-initiating cells. The agar-...
Accurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is crucial in clinic. The presence of collagen in the tumour microenvironment affects the metastasis of cancer cells. Herein, we propose a collagen signature, whic