The degree of selectin ligand expression by cancer cells is well correlated with metastasis and poor prognosis for cancer patients. Initial adhesion events of cancer cells facilitated by selectins result in activation of integrins, release of chemokines and are possibly associated with the formation of...
for Inhibition of Cancer Cell-Endothelial Interaction Diversity of Selectin Ligand Expression on Cancer Cells Internally Fucosylated Ligands for Selectins Sulfated Ligands for Selectins O-Acetylation and Other Sialic Acid Modifications in Carbohydrate Ligands Inhibitors of Selectin-Mediated Cell Adhesion Use ...
We considered it likely that the effects of 27HC on the biology of ER-negative cancer cells observed could be attributed to its established role as a negative regulator of cholesterol synthesis/uptake through its actions on both the SREBP and LXR dependent signaling pathways. Indeed, we found th...
A recent study implicates lysyl oxidase (LOX) as a HIF-1 target that mediates metastasis of human breast cancer cells in a mouse model and correlates with poor overall survival among estrogen receptor-negative breast cancer patients (Erler et al., 2006). LOX is required for the maturation of...
MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate...
deregulation of this complex machinery contributes to cancer progression and malignancy, enabling cells to acquire an invasive and metastatic phenotype. Metastasis accounts for 90% of death from patients affected by solid tumours, while an efficient prevention and suppression of metastatic disease still re...
and these genes are collectively known as the Src-responsive signature (SRS). 88.4% of ER+ cancer cells are SRS+, while only 23.0% of ER− tumors are SRS+, suggesting that luminal-type cancer cells may gain a survival advantage in the bone microenvironment [25]. Additionally, Smid et...
Then, these metastatic cancer cells anchor to distant vessel walls and extravasate into their destination tissues (Figure 3) before finally proliferating from microscopic growths to form secondary tumors. Figure 3 Tumor invasion and metastasis is a multilink, multistep complex process. Tumor cells ...
Metastasis EMT Cancer stem cells Autophagy 1. Introduction It is important to understand the molecular mechanism of metastasis so as to select a suitable therapeutic target for cancer treatment. The term “metastasis”, as a hallmark of cancer, was used for the first time by Jean Claude in 1829...
cancer cells, such as those affected by breast cancer oracutemyelogenousleukemia. The affinity of CXCR4-expressing cancer cells for CXCL12-secreting tissues results in the movement of the cancer cells from their primary sites of formation. Once the cancer cells bind to CXCL12 in the new tissue ...