DAB2IP regulates EMT and metastasis of prostate cancer through targeting PROX1 transcription and destabilizing HIF1α protein Prospero-related homeobox 1 (PROX1) is an essential regulator in lymphangiogenesis and has been implicated in both oncogenic and tumor-suppressive function... B Wang,J Huang,...
Interestingly, TGFβ treatment of human castration-resistant prostate cancer (CRPC) (PC3U) cells induced the secretion of multiple proteins (Fig. 1c) that were also consistently detected in our transcriptomic analysis. THBS1, also named TSP1, was recently identified as a non-invasive specific ...
Bone metastases are very common in advanced prostate cancer and can sensitively be detected utilizing PSMA-PET/CT. Therefore, our goal was to evaluate the suitability of PSMA-PET/CT-guided metastasis-directed external beam radiotherapy (MDT) as treatment option for patients with biochemical recurrence...
Colorectal cancer (CRC) shows high incidence and mortality worldwide, particularly in Western and developed countries. The objective of this study is to evaluate the oncologic results during a minimum follow-up of 2 years of curable CRC patients submitted to laparoscopic resection in our environment...
Non small cell lung cancer (NSCLC) is one of the most common cancers in the world. DHA is known to be capable of suppressing NSCLC cell proliferation and metastasis. However, the mechanisms by which DHA exhibits its antitumor effects are unknown. Here we aimed to identify the effects and me...
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic pr...
Finally, we present two promising and unsolved problems in cancer metastasis: targeted metastasis and tumor dormancy. And the classic theories behind these two questions: the pro-metastasis niche, vascular dormancy and immunological dormancy. Although recent research has offered important insight into the...
ARTICLE https://doi.org/10.1038/s41467-019-11020-3 OPEN Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes Esmee Koedoot1,4, Michiel Fokkelman 1,4, Vasiliki-Maria Rogkoti1,4, Marcel Smid2, Iris van de Sandt1, Hans de Bont1,...
As a key glycolysis enzyme, the significance of pyruvate dehydrogenase kinase 1 (PDK1) in the development of colorectal cancer (CRC) remains unknown. This study revealed that the prognosis of CRC patients with high levels of PDK1 was poor, and PDK1 knock
Hepatocellular carcinoma (HCC) is the sixth most common malignancy, with more than 626,000 new cases per year, and the third leading cause of cancer-related deaths worldwide.1,2 However, potentially curative therapies can only be applied in approximately 15% of these patients3 and the 5-year...