Metastasis-associated in colon cancer-1(MACC1) is an oncogene that was first identified in colon cancer. The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role
Metastasis-associate in colon cancer-1 (MACC1) has been identified as a metastatic and prognostic biomarker for colorectal cancer and other solid tumors. Aldehyde dehydrogenase 1 (ALDH1), a marker of cancer stem cells, is also associated with metastasis and poor prognosis in many tumors. However...
We identified the novel gene Metastasis Associated in Colon Cancer 1, MACC1, based on human colon cancer specimens [3]. In cell culture, MACC1 drives prolifera- tion, migration, invasion, wound healing and dissemin- ation and regulates genes transcriptionally important for metastasis, e.g. the...
MACC1, Metastasis associated in colon cancer 1, is a newly identified prognostic biomarker for colorectal cancer metastasis and patient survival, when determined in the primary tumor or patient blood. MACC1 induces cell motility and proliferation in cell culture and metastasis in mouse models. MACC1...
Associated content Collection One Year of Nature Cancer L1CAM links regeneration to metastasis Gloria Pascual Salvador A. Benitah Nature CancerNews & Views13 Jan 2020 Nature Cancer(Nat Cancer) ISSN2662-1347(online) Sign up for theNature Briefing: Cancernewsletter — what matters in cancer research,...
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The results showed that miR-145 expression was significantly decreased in CRC tissues compared with the paired adjacent normal tissues (Figure 1C). Although the expression level of miR-145 in rectal cancer was slightly lower than that in colon cancer (Slattery et al, 2011), there was no ...
26 In neuroblastoma and renal cancer cells, DKC1 inhibition slows tumour growth and reduces tumour’s metastatic capacity. DKC1 upregulation is associated with the poor prognosis of patients with prostate cancer,27 hepatocellular carcinoma,28 and neuroblastoma.29 Meanwhile, DKC1 acts as a tumour ...
SASH1-deficient, SASH1-depleted, or SASH1-overexpressing HCT116 colon cancer cells were generated by the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated 9-method, RNA interference, and transient plasmid transfection, respectively. Epithelial-mesenchymal transition (EMT) was analyz...
Prokaryotic Human Metastasis Associated In Colon Cancer 1| 基本信息更多信息 中文名称: 中文同义词: 英文名称:Prokaryotic Human Metastasis Associated In Colon Cancer 1 英文同义词:Prokaryotic Human Metastasis Associated In Colon Cancer 1 CAS号: 分子式: ...