Philadelphia Chromosome,Image Processing,oeep LearningPhiladelphia chromosome is a specific genetic abnormality, a reciprocal translocation between chromosome 9 and chromosome 22. This abnormality can cause Chronic Myelogenous Leukemia (CML). Although there are many techniques to diagnose Philadelphia chromosome...
When extended to the chromosome enumeration task, ChromTR also demonstrates state-of-the-art performances on R-band and G-band two metaphase image datasets. Given these superior performances to other methods, our proposed method has been applied to assist clinical karyotype diagnosis....
(Recommended value: 0.01) scale_ratio : Ratio of cell size to image size. (Recommended value: 0.4) nuclei_size_t : Size threshold for finding nuclei. Note: Nuclei smaller than nuclei_size_t will be considered erroneous signals. Rec: cultured images, use nuclei_size_t=5000. For tissue, ...
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Figure 1 – Microscope image of cells in various stages of mitosis Stages of Mitosis Prophase Each chromosome is made of two genetically identical chromatids, joined by a centromere. DuringDNA replication, genetic material is loosely packed aschromatin. However, during mitosis DNA needs to be more...
Full size image Fig. 6: Working model of non-canonical PKCε signalling in response to excess metaphase catenation. In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε. Here, we show...
Scanning force microscopy was used for mapping the viscoelastic properties of metaphase chromosomes. These properties were probed by scanning with various imaging forces and subsequent calculation of the difference image. The procedure allows a mapping of the viscoelastic behavior expressed as force-dependen...
Full size image A gelation transition enables long-range stress propagation Mixtures of filaments and motors can behave like fluids or gels depending on the filament connectivity35,36,37. To test whether a gelation transition underlies the long-range propagation of stresses in the spindle, we turned...
Home› Image Gallery› Image Gallery DetailA prometaphase muntjac skin fibroblast stained with Alexa Fluor® 350 phalloidin, an anti–a-tubulin antibody and an anti–cdc6 peptide antibody.A prometaphase muntjac skin fibroblast stained with Alexa Fluor® 350 phalloidin (Cat. no. A2...
Sign in to download hi-res image Fig. 2.Representation of cell proliferation mechanism. GC (growth factor); P (phosphate); GRB2 (receptor-bound protein 2); SOS (SOS protein); GDP (guanosine diphosphate); RAS (RAS protein); GTP (guanosine triphosphate); MAPK (mitogen-activated protein kinas...