Efforts in developmental drug metabolism in vitro with animal models are aimed at obtaining data which have some utility in predicting the clinical efficacy and/or toxicity of drugs. In vitro studies involving purified isoenzymes, subcellular fragments (nuclear, 9000 xgsupernatant, cytosolic and microso...
The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, the crosstalk between the gut microbiome and the host in r
The ratio of crotonyl-CoA to glutarate is highly regulated, and excessive glutarate accumulation can be cytotoxic26. Previous work on the cellular and physiological roles of glutarate has almost exclusively focused on patients with loss of function mutations in the GCDH enzyme, which results in exces...
All authors should have made substantial contributions to all of the following: The conception and design of the study, or acquisition of data, or analysis and interpretation of data. Drafting the article or revising it critically for important intellectual content. Final approval of the versio...
1p, which regulates Rgt1p and thus expression of hexose transporters via the cAMP/PKA pathway (Xue et al., 1998;Brown et al., 2014b). InC. albicansthe Snf3p/Rgt2p homologue Hgt4p is implicated in glucose sensing and regulation of the expression of at least six hexose transporter encoding...
Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROTAC) degrader
Maintenance of het- erogeneity may be driven by a population of cells within the tumor termed cancer stem cells (CSCs), which are highly plastic and responsive to their environment and hold self-renewal and tumor initiation capacity [4, 5]. At the single cell level, GBM is highly ...
Wheat (Triticum aestivum L.) is one of the most important cereal crops worldwide, ranking first terms of sowing area, production, and trade [1]. It is a staple food for approximately 40% of the world’s population [2]. Unfortunately, safe wheat production is threatened by diverse adverse...
Emerging evidence suggests that epigenetic regulation is dependent on metabolic state, and implicates specific metabolic factors in neural functions that drive behaviour1. In neurons, acetylation of histones relies on the metabolite acetyl-CoA, which is
l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the KP,...