The EndocrinologistSowers JR.The role of C-reactive protein in the metabolic syndromeand diabetes mellitus. Endocrinologist . 2007James R.Sowers. (2007) The Role of C-Reactive Protein in the Metabolic Syndrome and Diabetes...
Unlike other cells in the body, immune cells have to be able to enter and adapt to life within diverse tissues. Immune cells develop within dedicated immune system organs, such as the bone marrow, thymus and lymphoid tissues, but also inhabit other tissues, wherein they not only provide defe...
eIF4E binding protein 1 (4EBP1). A protein translation repressor. Its activity is inhibited by phosphorylation mediated by mTOR complex 1 to increase protein synthesis. Integrated stress response A mechanism that usually suppresses general protein synthesis but promotes the expression of specific transcri...
Evidence is produced that the skeletal muscles of the body, which weigh 21 times as much as the liver, form a major store for protein and act as a great metabolic regulatory organ which helps to maintain acceptable levels of aminoacids and glucose in the circulation. This concept has relevanc...
The concentration of a given protein in the cell depends not only on the magnitude of its synthesis but also on its degradation (p. 368). Enzymes are subjected to continual renewal, according to their half-lives (time by which 50% of the enzyme is degraded), which ranges from minutes to...
[25]Kola, B. “Role of AMP-Activated Protein Kinase in the Control of Appetite.” Journal of Neuroendocrinology, vol. 20, no. 7, July 2008, pp. 942–951, 10.1111/j.1365-2826.2008.01745.x; https://www.ncbi.nlm.nih.gov/pmc...
Yet, seldom have approaches been developed to study the functional role of microorganisms in the context of biogeochemistry and community-level functional networks [27, 28]. Such tools are based on the principles of facilitating the understanding of microbially mediated biogeochemical activities. The too...
Given the critical role of lipids in cancer progression, targeting to lipid metabolism-related pathways offers new therapeutic opportunities for cancer. A large body of evidence shows that inhibitors targeting lipid uptake, lipogenesis, and FAO in tumor cells have shown significant therapeutic effects in...
of the deteriorating effect of a protein diet on aging and related disorders. In this review, we delineate the regulation of metabolic pathways for BCAAs at the tissue-specific level and summarize recent findings regarding the role of BCAAs in the control of metabolic health and disease in ...
Despite being a well-known phenomenon, to date, we have only identified a few publications that explicitly looked at the role of sex in the response to HFD in mice.11–14 Typically with metabolic studies, the treatment will be associated with a weight change. However, body weight is known ...