Tollesfsbol, TO, Cohen, JH (1986) Role of protein molecular and metabolic aberrations in aging, in the physiologic decline of the aged, and in age-associated diseases. J Am Geriatr Soc 34: pp. 282-94Tollefsbol TO, Cohen HJ: Role of protein molecular and metabolic aberrations in aging,...
eIF4E binding protein 1 (4EBP1). A protein translation repressor. Its activity is inhibited by phosphorylation mediated by mTOR complex 1 to increase protein synthesis. Integrated stress response A mechanism that usually suppresses general protein synthesis but promotes the expression of specific transcri...
Unlike other cells in the body, immune cells have to be able to enter and adapt to life within diverse tissues. Immune cells develop within dedicated immune system organs, such as the bone marrow, thymus and lymphoid tissues, but also inhabit other tissues, wherein they not only provide defe...
This data again suggests a role of EIIANtr in the metabolism of glycerol. 3.4. Metabolomic analysis Important metabolic enzymes were identified among the putative EIIANtr binding partners, particularly when the phosphomimic version EIIANtr - H73D was used as bait. If these identified protein ...
Accordingly, GSK3 modulates metabolic processes, including protein and lipid synthesis, glucose and mitochondrial metabolism, as well as autophagy. In this review, we highlight current knowledge of the role of GSK3 in metabolic perturbations in cancer....
It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of many metabolic diseases, including obesity...
Metabolic control of cell death A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria versus endoplasmic reticulum Hypothalamic AMPK: a canonical regulator of whole-body energy balance Regulation Mechanisms and Signaling Pathways of Autophagy. Apoptosis, autophagy & endoplasmic ret...
of PD, and changes in NURR1 expression can have a detrimental effect on cellular metabolism. In this review, we discuss recent evidence that suggests a vital role of NURR1 in dopaminergic (DAergic) neuron development and the pathogenesis of PD. The association between NURR1 and cellular ...
Despite being a well-known phenomenon, to date, we have only identified a few publications that explicitly looked at the role of sex in the response to HFD in mice.11–14 Typically with metabolic studies, the treatment will be associated with a weight change. However, body weight is known ...
Obesity is a health condition that has reached pandemic levels and is implicated in the development and progression of type 2 diabetes mellitus, cancer and heart failure. A key characteristic of obesity is the activation of stress-activated protein kinas