Although the underlying mechanisms and mediators of AD are not well understood, accumulating evidence supports the role of dysregulation of VSMCs, ECs, and vascular extracellular matrix in pathogenesis of AD. Risk factors related to CRS and misregulation of adaptive metabolic responses develop a ...
Neutral lipids play a crucial role in bioenergetics and membrane biogenesis. Lipotoxicity, resulting from excessive accumulation of fatty acids, glycerolipids, and sterols, underscores the crucial role of neutral lipid synthesis and accumulation within cells [16]. These lipids can induce cellular stress...
Given the critical role of lipids in cancer progression, targeting to lipid metabolism-related pathways offers new therapeutic opportunities for cancer. A large body of evidence shows that inhibitors targeting lipid uptake, lipogenesis, and FAO in tumor cells have shown significant therapeutic effects in...
Many human diseases, including metabolic, immune and central nervous system disorders, as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their pathways. This illustrates the fundamental role played by lipids in maintaining membrane homeostasis and normal function in...
HNE can damage pancreatic β cells and can impair the ability of muscle and liver cells to respond to insulin. HNE may promote atherosclerosis by modifying lipoproteins and can cause cardiac cell damage by impairing metabolic enzymes. An adverse role for HNE in the brain in obesity and the ...
Thus, the role of Cer in cell death suggests that Cer metabolism is an attractive therapeutic target. Several studies have examined Cer-based therapies involving agents that increase Cer level for cancer treatment. For example, taxol induces cellular Cer generation in breast cancer cells (MCF-7 ...
Beyond this aspect, multiple ontologies used to describe metabolites/lipids54 and the semi quantitative property of most of the analytical methods, are still major bottlenecks of the field. Despite these limitations, it is now recognized that metabolomics is a powerful tool allowing metabolic ...
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrat... ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de...
et al. The Modulated Role of TG-DHA Liposome on the Appetite of High Fat Diet-fed Mice | [TG-DHA 脂质体对高脂饮食小鼠食欲的调节作用]. Science and Technology of Food Industry, 2021, 42(12): 340-346. doi:10.13386/j.issn1002-0306.2020080274 12. Anastasiou, G., Sakka, E., Blathra,...
Nutrient and lipid deprivation renders cancer cells completely dependent on endogenous FA synthesis and desaturation. However, in conditions of hypoxia combined with nutrient and lipid deprivation, exogenous lipids are also in short supply. Hence, the cells switch back to de novo FA synthesis, but fu...