Commonly known as the aerobic pathway, this energy system is primarily active during easy to moderate exercise. Aerobic training involves getting the body more efficient at delivering blood to the working muscles, with oxygen present. You can go for hours using this energy system, because you have...
A PML–PPAR–delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat. Med. 18, 1350–1358 (2012). CAS PubMed PubMed Central Google Scholar Tohyama, S. et al. Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-...
The kinetic properties of MFE-1 allows together with CYP3A11 and CYP46A1 to make an Amacr-independent pathway for the generation of C24 bile acids [57]. It has been demonstrated that the rat peroxisomal MFE-1 can rescue the growth of a mfe-2 null mutant yeast strain on oleic acid which...
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received considerable attention, pancreatic fat has become an important area of resear
Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Adipose tissue lipolysis is the catabolic process leading to the breakdown of triglycerides stored in fat cells and release of fatty acids and glycerol. Re... D Langin - ...
PFK is a key regulatory enzyme in the glycolytic pathway, which is responsible for the breakdown of glucose to generate ATP. PFK controls the rate-limiting step of glycolysis, converting fructose-6-phosphate to fructose-1,6-bisphosphate. Changes in PFK activity or regulation can affect the rate...
If these reactions occur at the same time, the energy generated by one pathway is used by the other pathway without efficient use. This phenomenon is called a futile cycle, where this occurs due to independent control by each pathway. A similar phenomenon can be seen for Ppc and Pck for ...
Furthermore, inhibition of the pentose phosphate pathway (PPP) protects against this synergistic toxicity [149]. Apart from its essential role in antioxidant defense and nucleic acid synthesis, PPP provides nicotinamide adenine dinucleotide phosphate for fatty acid and cholesterol biosynthesis [149,150,...
In breast cancer, p53 mutants have been shown to promote cancer progression by increasing cholesterol synthesis through enzymes involved in upregulation of the mevalonate pathway, highlighting the potential to target this pathway for p53-mutated tumors [80]. Moreover, the expression of genes key to...
Targeting the TGFβ signalling pathway in disease. Nat. Rev. Drug Discov. 11, 790–811 (2012). CAS PubMed PubMed Central Google Scholar Rangarajan, S. et al. Novel mechanisms for the antifibrotic action of nintedanib. Am. J. Respir. Cell Mol. Biol. 54, 51–59 (2016). CAS PubMed...