Meta-analysis of transcriptomics data identifies potential biomarkers and their associated regulatory networks in gallbladder cancerdoi:10.22037/ghfbb.v15i4.2292RNA physiologyBIOMARKERSGALLBLADDER tumorsMETA-analysisMICRORNAGENE expression profilingAim: This study aimed to identify key genes,...
Zebrafish have the capacity to fully regenerate the heart after an injury, which lies in sharp contrast to the irreversible loss of cardiomyocytes after a myocardial infarction in humans. Transcriptomics analysis has contributed to dissect underlying sig
Transcriptomics data from single experiments provide an informative but selective view of biological processes. There is an increasing evidence, however, that mining microarray data simultaneously from many different experiments and organisms make this type of data highly informative and valuable for ...
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Still, various factors limit the meta-analysis of RNA-seq studies. Among these are variations in experimental design, sequencing technology, and statistical method, to name a few. With the reduction in sequencing costs, comparative transcriptomics has significantly broadened the potential for inter-...
PD-1 and PD-L1 inhibitors have emerged as promising therapies for advanced colorectal cancer (CRC), but their efficacy and safety profiles require further evaluation. This meta-analysis aims to assess the efficacy and safety of PD-1/PD-L1 inhibitors in t
The Heart Cell Atlas v2 represents an extensive resource for single-cell, cardiac transcriptome data and was therefore used to specifically analyze spatial transcriptomics in the heart. Clustering of mRNA expression during human tissue development We generated a Python script training a SOM (self-...
of developing PD than participants without infection, and a subsequent meta-analysis2suggested that patients with HCV infection may have an increased risk of developing PD. In addition, antiviral medication against HCV has been shown to reduce the incidence of PD in people with HCV infection, even...
Detailed analysis of differential expression identified meta-signatures for each hepatic immune subpopulation. Herein, we introduce a novel and rigorous framework for meta-analysis of scRNA seq datasets and highlight profiles of liver immune homeostasis. 展开 ...
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor al