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In this study, we report the structures of the Neisseria meningitides MetQ in substrate‐free form and in complexes with L﹎ethionine and with D﹎ethionine, along with the associated binding constants determined by isothermal titration calorimetry. Structures of the substrate‐free (N238A) and ...
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5a, b). In an unphosphorylated state, Tyr434 does not form any significant interaction with this motif. However, in contrast to NEDD4, tyrosine phosphorylation at Tyr434 enhances the binding between C2 and HECT domains. We observe that phosphorylation at Tyr434 changes the local electrostatic ...
HGF is secreted by mesenchymal cells as a single-chain, biologically inert precursor and is converted into its bioactive form when extracellular proteases cleave the bond between Arg494 and Val4957. The mature form of HGF consists of an α- and β-chain, which are held together by a ...
The non-specific presentation and the temporal delay between the exposure and the clinical onset explain why it is the imported form of schistosomiasis that is most likely to be misdiagnosed in non-endemic countries [14]. Which specific laboratory tests should be used in patients with ...
Houd rekening met de uitzonderingen die worden weergegeven inActies die een onverwachte werking kunnen veroorzakenwanneer u in de modus Vrije vorm werkt.
in any way, shape or form,15200:12:06,519 --> 00:12:11,441is that men and women can't be friends,cos the sex part always gets in the way.15300:12:12,941 --> 00:12:17,281That's not true. I have a number ofmen friends and there is no sex involved.154...
Then, cells were resuspended with serum-free medium and added into the upper chamber of the trans-well insert (2 × 105 cells/well). The 10% FBS-containing DMEM was added in the lower chamber. Cells were incubated h at 37°C for 36 h. Migrated cells were fixed with 4% formaldehyde ...
Accordingly, compounds as defined by the term “Formula I, II or III” include both the free base and salt forms. The acids that may be used to prepare pharmaceutically acceptable acid addition salts of such basic compounds of formulas I and II are those that form non-toxic acid addition ...