三代EGFR-TKI奥希替尼是国内外指南一致推荐的EGFR突变阳性晚期非小细胞肺癌(NSCLC)标准一线治疗方案,生存获益显著且安全性良好,自上市以来造福了无数患者。然而,由于其耐药机制较为复杂,部分医生担心耐药后“无药可用”,因此不愿“好药先行”。实际...
Metyltetraprole;Metyltetraprole 100 μg/ml Acetonitrile;Metyltetraprole 100.0 μg/ml Acetonitrile;5H-Tetrazol-5-one, 1-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]-3-methylphenyl]-1,4-dihydro-4-methyl-;1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methy...
TEL M10-301095-1 BAFFLE PLATE (3) (N.P.C) TEL M10-301303-2 SEAL BLOCK (B) (COLLING) TEL M10-301307-3 BOTTOM ELECTRODE TEL M10-301917-1 ELECTRODE PLATE TEL M10-302156-2 GATE LEAKAGE, BASE MOUNT, B2 TEL M10-302999-2 REINFORCING PLATE (2)1.8G 16 TEL M10-400089-2 RETAINER (PACK...
1. 高硬度:MET-STiN涂层的硬度可高达Hv3000,比普通的氮化钛高出Hv600,可以提高模具的硬度和耐磨性。 2. 耐磨性:MET-STiN涂层可以提高模具的耐磨性,从而延长模具的使用寿命。 3. 适用范围广:MET-STiN涂层适用于塑料模具,如塑料瓶杯磨具,可以提高模具的质量...
R., Jr ., Mills, G. B. & Gonzalez-Angulo, A. M. Targeting the hepatocyte growth factor-cMET axis in cancer therapy. J Clin Oncol 30, 3287–3296 (2012). Article CAS Google Scholar Sonnenberg, E., Meyer, D., Weidner, K. M. & Birchmeier, C. Scatter factor/hepatocyte growth ...
Lu X, Feng X, Man X, Yang G, Tang L, Du D et al. Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression. Clin Cancer Res 2009; 15: 3287–3296. Article CAS PubMed Google Scholar Lisovsky M, Dresser K, Woda B, Mino-Kenudson M . Immunohistochemistry for...
R., Jr., Mills, G. B. & Gonzalez-Angulo, A. M. Targeting the hepatocyte growth factor-cMET axis in cancer therapy. J Clin Oncol 30, 3287–3296 (2012). 7. Sonnenberg, E., Meyer, D., Weidner, K. M. & Birchmeier, C. Scatter factor/hepatocyte growth factor and its receptor, the...
c-MET and its ligand hepatocyte growth factor are often dysregulated in human cancers. Dynamic changes in c-MET expression occur and might predict drug eff
www.nature.com/scientificreports OPEN c-MET as a Potential Therapeutic Target in Ovarian Clear Cell Carcinoma received: 17 June 2016 accepted: 10 November 2016 Published: 05 December 2016 Ha-Jeong Kim1,*, Aera Yoon2,*, Ji-Yoon Ryu2,*,Young-Jae Cho2, Jung-Joo Choi2, Sang...
We therefore concluded that Yhhu3813 inhibits c-Met-mediated cell proliferation by inducing G1/S arrest. Cell line EBC-1 MKN-45 SNU-5 BaF3/TPR-Met IC50 (nmol/L) 88.3±8.4 127.6±8.3 76.6±13.2 49.8±13.5 Yhhu3813 inhibits c-Met-dependent cell migration, invasion, and scattering In ...