Furthermore, c-Met-targeted CAR-T cells have shown good antitumor activity in preclinical studies of GC [29, 30]. Since adoptive immunotherapy mainly relies on the particular expression of c-Met on the cell membrane of GC, it is not limited to the carcinogenic mechanism of c-Met. This ...
因此,在本发明的另一个实施方案中,描述一种将经诊断患有胃癌的患者筛选为对抗HGF抗体治疗有反应的方法,其包括测定获自经诊断患有胃癌的患者的样品中存在有c-Met蛋白质的肿瘤细胞的百分比的步骤,其中至少1%百分比的具有c-Met蛋白质的肿瘤细胞预测患有胃癌的患者将对抗HGF抗体治疗有反应。 [0013]在本发明的这些方面的...
T., Yoshikawa, S., & Ambady, N. (2010). Cross-cultural reading the mind in the eyes: An fMRI investigation. Journal of cognitive neuroscience, 22(1), 97-108. Baron-Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997). Another advanced test of theory of mind: ...
Wagner, C.: J. chem. Phys. 21, 1819 (1953). CAS Google Scholar Gwathmey, A. T., u. K. R. Lawless: The Influence of Crystal Orientation on the Oxidation of Metals, in the Surface Chemistry of Metals and Semiconductors, ed. by H. C. Gatos, S. 483ff. New York: J. Wiley &...
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In alle andere gevallen wordt de stand-bytimer ingesteld op de huidige waarde van de wachtstandtijd die door deze router wordt gebruikt. Vervolgens start de stand-bytimer. C Stop actieve timer: De actieve timer stopt. D Stop stand-bytimer: De standby-timer stopt. E Leer parameters: ...
To compare the binding properties of the compounds, we performed independent t-tests for each interaction distance, using crizotinib and cabozantinib as controls for c-Met and VEGFR-2, respectively. Mean differences were calculated, and statistical significance was set at p < 0.05. In addition, ...
Oncotarget 2017, 8, 102721–102738. [CrossRef] 14. Ide, T.; Kitajima, Y.; Miyoshi, A.; Ohtsuka, T.; Mitsuno, M.; Ohtaka, K.; Miyazaki, K. The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c...
A combination of foretinib and lapatinib effectively reduced the viability of examined cells, led to G2/M arrest and reduction of pAKT. There was also a decreasein number of invadopodia formed by cells, their ability to digest gelatin and reduction of cells migration/invasion capacity. Therapy ...