TIDE algorithm and neural network were utilized to assess the predictive accuracy of MSC-related genes for immunotherapy. Results: MSC-related gene expression significantly differed between normal and tumor samples across the 33 cancer types. Cox regression analysis suggested the MSC score as an ...
Increasing matrix stiffness caused by the extracellular matrix (ECM) deposition surrounding cancer cells is accompanied by epithelial–mesenchymal transition (EMT). Here, we show that expression levels of EMT marker genes along with discoidin domain rece
cancer cells and promote cancer, are embryonic neural genes, whereas the typical epithelial geneE-cadherin, a tumor suppressor gene [153,154], is expressed in epidermis only, excluding embryonic neural tissues [152]. These patterns of EMT gene expression match very well with the rules about cance...
as the aging of MSCs leads to an age-associated decline in their number and function, it is important to clarify the age-associated factors and regulatory mechanism associated with the MSC aging process.In this review, we amass and discuss the recent data related to age-associated genes in MS...
[43] observed that hypoxia inducible factor (HIF)-1α in MSC-EVs stimulated the expression of relevant osteogenic genes, rescuing bone ischemic necrosis by mitigating early steroid induction. Additionally, tsRNA-10277-containing MSC-EVs were found to regulate the lipogenic and osteogenic potential of...
Further, enhanced expression of stemness genes was also detected. Among several EMT-related miRNAs, miR-200c-3p expression resulted as the most strongly suppressed. Interestingly, we also found a significant upregulation of Follistatin-related protein 1 (FSTL1), a miR-200c predicted target ...
[43] observed that hypoxia inducible factor (HIF)-1α in MSC-EVs stimulated the expression of relevant osteogenic genes, rescuing bone ischemic necrosis by mitigating early steroid induction. Additionally, tsRNA-10277-containing MSC-EVs were found to regulate the lipogenic and osteogenic potential of...
S. (2013). Aging-related genes in mesenchymal stem cells: a mini-review. Gerontology 59, 557-563. doi: ... Y Onodera,T Teramura,T Takehara,... - 《Aging Cell》 被引量: 1发表: 2017年 Cannabidiol Modulates the Expression of Alzheimer’s Disease-Related Genes in Mesenchymal Stem Cells...
Given the relevance of E-cadherin in tumour development and progression and the different mechanisms involved in its regulation, we set out to use a genome-wide expression analysis to identify genes or pathways in mammary epithelial cells that are either (in)directly affected by loss of E-...
The functional genes at the downstream of TWIST1 were obtained via microarray gene expression analyses in the NSCLC cell line. The expression levels of synaptotagmin 7 (SYT7) in a cohort of patients with NSCLC (n = 154) were examined using immunohistochemistry staining and assessed by Kaplan-...