(2015) Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy. Clinical and Translational Science , n/a-n/a /...
T1DM is an autoimmune disease that is caused by the destruction of insulin-secreting pancreatic β-cells that leads to the elevation in glucose levels in the blood (hyperglycemia) [77]. Currently, there is no cure for T1DM, and treatment with insulin injections is the only option [78]. In ...
Nevertheless, a recent case report on a patient with severe lupus nephritis, who had received percutaneous intrarenal injections of autologous peripheral stem cell preparations in a private clinic, seems to confirm the possibility of stem cell maldifferentiation in humans: The cell injections apparently...
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine ac...
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it has been demonstrated that the production of vari...
54 mice were randomly assigned to injections with i) MSC secretome from 20,000 MSCs, ii) 20,000 MSCs or iii) medium (control). Pain was assessed by hind limb weight distribution. Cartilage damage, subchondral bone volume and synovial inflammation were evaluated by histology. MSC-secretome- ...
Injections were performed two days after infarction and the arrhythmogenic inducibility experiment was performed the next day. Only 35% of the MI+MSCs group developed VAs, while the one in the MIV group was 65%. The proportion of nonsustained ventricular tachycardia, sustained tachycardia, and ...
T1DM, also known as autoimmune diabetes, arises from the autoimmune-mediated β-cells apoptosis and dysfunction, resulting in the patients depend on lifelong therapy involving exogenous insulin injections [30]. T1DM arises as a consequence of a complex dialog between immune cells and T cells inside...
Mesenchymal stem cell (MSC)-based therapy for type 1 diabetes mellitus (T1DM) has been the subject matter of many studies over the past few decades. The wide availability, negligible teratogenic risks and differentiation potential of MSCs promise a therapeutic alternative to traditional exogenous insul...
MSCs were diluted to a final cell density of 107 MSCs in 50 µL of native rat serum. A 1 mL syringe with a 23 G needle was used to deliver cells in a slow and steady injection into cell cultures dishes, mimicking the injections that were performed for intra-articular delivery ...