Although the best characterized Treg cells have the CD4+CD25+phenotype, CD8+T-cell populations have also been shown to possess immunosuppressive function, including CD8+CD28−, CD8+CD25+and CD8+IL-10+T cells, which can inhibit the activation and proliferation of lymphocytes.12,14,15CD8+CD28...
dependent reduction of the stem cells’ potential for adipogenic, chondrogenic and osteogenic differentiation. The influence of taxanes on differentiation of human MSCs has been subject to previous investigations as the differentiation potential is a key requirement for these stem cells’ regenerative funct...
3.4Mesenchymal Stem Cells Mesenchymal stem cells (MSCs) derived from bone marrow or umbilical cord blood are able to differentiate into various somatic cells (e.g., osteoblasts) for drug testing. MSCs, however, have limited activity and growing them in vitro is a slow and burdensome process.Me...
choice for cell therapy [18]. Mesenchymal stem cells have paracrine activities that include promotingangiogenesis, inhibitingapoptosis, reducing inflammation, and, most significantly, immunomodulatory functions. To govern the healing process aftertissue injury, they often begin their immunomodulatory function ...
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it
These cells participate in inflammation, host defense, tissue-specific function, and homeostasis. Macrophages are traditionally classified into classically activated M1 phenotype and alternatively activated M2 phenotype, which is oversimplified to account for phenotypes observed under different conditions. During...
function, balance T-helper (Th)1 and Th2 activity [69,70], upregulate the functions of regulatory T cells (Tregs) [71], suppress B cell functions [72,73], inhibit natural killer (NK) cell proliferation and function [74], and prevent dendritic cell (DC) maturation and activation [6,57...
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–9. Article CAS PubMed Google Scholar Van Niel G, Porto-Carreiro I, Simoes S, Raposo G. Exosomes: a common pathway for a specialized function. J ...
(ECM) and regulating development, homeostasis and repair of tissues. Recent detailed mechanistic insights into the biology of fibroblastic mesenchymal cells have revealed they are also significantly involved in immune regulation, stem cell maintenance and blood vessel function. It is now becoming evident...
et al. Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine Effects. Sci. Rep. 6, 28250; doi: 10.1038/srep28250 (2016). Change history 02 September 2016 A correction has been published and is appended to both the HTML and...