The efficacy of sustained-release preparations of mesalazine as a remission maintenance treatment for Crohn's disease remains to be established. We aimed to examine the changes in compliance rate and clinical data 2 years after switching from mesalazine tablet to granule formulation at our facility ...
Prolonged-release mesalazine acts topically in the affected bowel lumen. In volunteers, 18 to 20% of the administered dose was delivered to the jejunoileal segment as solubilised drug, while cumulative colonic delivery was 82% (approximately 75% as intact microgranules) during the first 7 hours...
A batch for the production of 180,000 sachets of prolonged release granules was provided as follows. ConstituentsQuantitySpecification Mesalazine180kgFerring Povidone9kgPh. Eur. Water, purified33.3kg**Ph. Eur. Ethylcellulose1.9kg***Ph. Eur. ...
Methods In a multicenter, prospective, observational study, outpatients with active or quiescent \\{UC\\} were enrolled if they were receiving, or were planned to receive, sustained release mesalazine microgranules (Pentasa®). Clinical and prescribing data were collected at study entry, after 2...