The study focussed on designing a Stimuli-Synchronized Matrix (SSM) for space-defined colonic delivery of the anti-inflammatory drug mesalamine. The configured matrix provided time-independent delivery and stim
43 The release profile of the mesalamine formulation used in this study (Salofalk granules) is comparable with that of Apriso,45, 46 but reveals marked differences from other commercially available mesalamine formulations (eg, Asacol, Pentasa).47, 48 Given the colonic topography of the disease and...
N-acetyl-5-aminosalicylic acid in human milk in small amounts with relative infant doses (RID) of 0.1% or less for mesalamine (seeData). There are case reports of diarrhea observed in breastfed infants exposed to mesalamine (seeClinical Considerations). There is no information on the effects...
an aminosalicylate. DELZICOL (mesalamine) delayed-release capsules contain acrylic based resin, Eudragit S (methacrylic acid copolymer type B, NF), which dissolves at pH 7 or greater and releases mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the...
To overcome this drawback, 5-ASA-loaded xylan microcapsules were produced by spray-drying process, an alternative that avoids the use of cross-linking agents (Silva et al., 2013). However, the kinetic release of the drug from the microparticles showed that spray-dried formulations completely ...