70,85] or MNT test. [74,85,86] This confirmatory process aims toensure the antibodies detected are able to specifically neutralize the intended virus and are not more broadly reactive to other coronaviruses found in DCs (bovine CoV, BCoV) or humans (HCoV-OC43, HCoV-229E, HCoV-NL63, HC...
The first known cases of Middle East respiratory syndrome (MERS), associated with infection by a novel coronavirus (CoV), occurred in 2012 in Jordan but were reported retrospectively. The case first to be publicly reported was from Jeddah, in the Kingdom of Saudi Arabia (KSA). Since then, ...
In mid 2012, a novel coronavirus (CoV) was isolated form the sputum of a patient with acute pneumonia and renal failure [1]. As of July 10th 2013, this virus, named Middle East respira- tory syndrome (MERS)-CoV, has caused 80 laboratory-confirmed infections of which 44 were fatal [2]...
Recombination of MERS-CoV. We performed the recombination analysis on the collected full-length MERS-CoV sequences. We find that there are 28 of them experienced potential recombination events (30.4%, 28/92), including three camel MERS-CoVs and 25 human MERS-CoVs (supplementary Table 1)....
full immu nity in the camels and viral nucleic acid was detected in such animals though at a significantly lower level 16 these and other recent results however require confirmation Evidence was provided that MERS CoV has been circu lating in camels at least since 1992 14 but probably much ...
Download: Download full-size image Figure 1. Schematic diagram of the potential zoonotic transmission of MERS-CoV. Further evidence for the involvement of a specific animal species as an (intermediate) host comes from studies analyzing the host antibody response to MERS-CoV or closely related viruse...
The RBD core subdomain and SD1 form quaternary interactions with the NTD to stabilize the disassociated S1 trimer. Full size image The SARS-CoV S trimer can be classified into two classes with all three RBDs in the lying state (56% of particles) or two lying RBDs and one standing RBD ...
Full size image Comparison We observed that the strength of the reaction to the H7N9 outbreak (peak: 33,904 posts per million posts on April 5, 2013; keywords “禽流感” (avian flu) and “H7N9”) was two orders of magnitude stronger than the reaction to the MERS-CoV outbreak (peak: 34...
The spike glycoprotein (S) of recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) targets the cellular receptor, dipeptidyl peptidase 4 (DPP4). Sequence comparison and modeling analysis have revealed a putative receptor-binding domain (RBD) on the viral spike, which mediates th...
In May 2014, Middle East respiratory syndrome coronavirus (MERS-CoV) infection, with closely related viral genomes, was diagnosed in two Dutch residents, r