(fibrates), including clofibrate, fenofibrate and bezafibrate, (v) cholesterol absorption inhibitors, such as ezetimibe, (vi) acyl CoA:cholesterol acyltransferase (ACAT) inhibitors, such as avasimibe, (vii) phenolic anti-oxidants, such as probucol, and (viii) a microsomal triglyceride transfer ...
cholesterol reducing agents such as probucol and HMG-COA reductase inhibitors such as pravastatin, or lovastatin and simvastatin in the open hydroxy acid form; antibiotics such as doxycycline, minocycline, erythromycin, clindamycin, gentamicin, tobramycin, spectinomycin, mithramycin, rifampin; antifungal agen...
Members of the class of HMG-CoA reductase inhibitors, known as the “statins,” have been found to trigger the growth of new bone, replacing bone mass lost as a result of osteoporosis (see The Wall Street Journal, Friday, Dec. 3, 1999, page B1). Therefore, the statins hold promise for...
These drugs inhibit HMG-CoA reductase, the rate limiting enzyme for the production of polyisoprenoids and the farnesyl pyrophosphate precursor. It has been shown that a farnesyl-protein transferase using farnesyl pyrophosphate as a precursor is responsible for Ras farnesylation. (Reiss et al., Cell...
(R5)2 and/or NR5COA′, Ar denotes phenyl, biphenyl or naphtyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, Het1, (CH2)nOR5, (CH2)nN(R5)2, NO2, CN, (CH2)nCOOR5, CON(R5)2, CONH(CH2)qNHCOOA′, CON[R5(CH2)nHet1], NR5COA, NHCOOA, NR...
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## Inventors: Inamine, Edward S. (Rahway, NJ) Hensens, Otto D. (Red Bank, NJ...
(DSG), cholesterol biosynthesis inhibitors such as HMG CoA reductase inhibitors (lovastatin and simvastatin), non-steroidal antuinflammatory drugs (NSAIDs) such as ibuprofen and cyclooxygenase inhibitors such as rofecoxib, steroids such as prednisone or dexamethasone, gold compounds, antiproliferative ...
(iii) proliferator-activater receptor α agonists such as fenofibric acid derivatives (gemfibrozil, clofibrate, fenofibrate and benzafibrate), (iv) inhibitors of cholesterol absorption for example beta-sitosterol and (acyl CoA:cholesterol acyltransferase) inhibitors for example melinamide, (v) probucol,...
(e) cholesterol lowering agents such as (i) HMG-CoA reductase inhibitors (lovastatin, simvastatin and pravastatin, fluvastatin, atorvastatin, and other statins), (ii) sequestrants (cholestyramine, colestipol and a dialkylaminoalkyl derivatives of a cross-linked dextran), (ii) nicotinyl alcohol nico...
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