of each daily dose of 0路1 gm. is degraded. The rate of degradation of mepacrine in blood has been found to be proportion to the rate of degradation in the tissues, and both rates are directly related to the respective concentrations of the drug in blood and tissues. Assessment of the ...
Mepacrine was found to exert a dose-dependent inhibition of prostaglandin E2 synthesis in rabbit kidney medulla slices and in medullary microsomes. Mepacrine at 0.5 mM produced 90% inhibition of microsomal prostaglandin E2 biosynthesis from added arachidonic acid. This effect results from inhibition of ...
The phase I study of imatinib, a small molecule inhibitor of the BCR-ABL tyrosine kinase, had identified no maximally tolerated dose, and 53 of 54 patients achieved a complete hematologic response31; based on these results as well as those of 3 phase II studies, imatinib was granted ...
Trophozoites and schizonts were no longer found after a single dose of 20 mg/kg or five doses of 1.25 mg/kg of salinomycin whereas a single dose of 40 mg/kg or five doses of 20 mg/kg of lasalocid showed no marked effect on parasitaemia within 96 h of starting treatment in rats. ...
A dose of 100mg a day, tapered to weekly doses once remission is obtained, seems feasible. Except for (mild) yellow skin discoloration, the drug has few side-effects, and offers the advantage of not displaying retinal toxicity.Conclusion: Mepacrine is still a useful and safe drug for ...
Using prelabeled slices, a dose-dependent decrease in the 14C-radioactivity in PE and PC was observed, with a parallel increase in PI. This effect of Mp persisted even in the presence of a physiological activator of phospholipase A 2, bradykinin (BK). No change in the net amount of ...
Thrombin induced mepacrine release in a dose-dependent manner from 0.003 to 0.4 U/ml. Therefore both platelet uptake and release of mepacrine can be readily detected by flow cytometry. Flow cytometry provides an attractive alternative to aggregation and radioactive serotonin as methods to study ...
Infusion of mepacrine or quinidine (2–10 μg/ml) into the rabbit ear reduces the algesic effect of bradykinin as well as of acetylcholine in proportion to the dose. Infusion of postglandin E 1 (10 ng/ml) in addition to mepacrine or quinidine restores the inhibited algesic effect of ...
Trophozoites and schizonts were no longer found after a single dose of 20 mg/kg or five doses of 1.25 mg/kg of salinomycin whereas a single dose of 40 mg/kg or five doses of 20 mg/kg of lasalocid showed no marked effect on parasitaemia within 96 h of starting treatment in rats. ...
There was great variation in individual excretion, in some cases up to 30 per cent. of the administered dose being eliminated by the bowel. The amount excreted in the ...doi:10.1080/00034983.1946.11685296NoneTaylor & FrancisAnnals of Tropical Medicine & Parasitology...