Biopsy revealed metastasis of the meningioma, now with 2.7 mitoses/mm2, necrosis and homozygous CDKN2A/B deletion, corresponding to an anaplastic CNS meningioma WHO grade 3. A second small meningioma on the left petroclival side has been consistent in size over 12...
Human WHO grade Imeningiomaderived, hTERT immortalized (Ben-Men-I) cells were cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% FCS, 2 mMl-glutamine, and 1 mMsodium pyruvate(Sigma-Aldrich). HumanneuroblastomaSH-SY5Y were cultured in DMEM supplemented with 15% FCS, 2 ...
In addition, the hSDF1alpha-induced cell proliferation was significantly correlated with the MIB1 staining index in the corresponding surgical specimen. In conclusion, we found that human meningiomas express CXCR4 and SDF1 and that hSDF1alpha induces proliferation in primary meningioma cell cultures ...
A strong preponderance was seen in the variant of meningothelial meningioma WHO grade I of basal and spinal localization. In contrast, E17K mutations were rare in WHO grade II and absent in WHO grade III meningiomas. In order to more effectively detect this mutation, we tested for ...
In addition, the hSDF1α-induced cell proliferation was significantly correlated with the MIB1 staining index in the corresponding surgical specimen. In conclusion, we found that human meningiomas express CXCR4 and SDF1 and that hSDF1α induces proliferation in primary meningioma cell cultures through...