Biopsy revealed metastasis of the meningioma, now with 2.7 mitoses/mm2, necrosis and homozygous CDKN2A/B deletion, corresponding to an anaplastic CNS meningioma WHO grade 3. A second small meningioma on the left petroclival side has been consistent in size over 12...
Human WHO grade I meningioma derived, hTERT immortalized (Ben-Men-I) cells were cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% FCS, 2 mM l-glutamine, and 1 mM sodium pyruvate (Sigma-Aldrich). Human neuroblastoma SH-SY5Y were cultured in DMEM supplemented with 15%...
In addition, the hSDF1α-induced cell proliferation was significantly correlated with the MIB1 staining index in the corresponding surgical specimen. In conclusion, we found that human meningiomas express CXCR4 and SDF1 and that hSDF1α induces proliferation in primary meningioma cell cultures through...