The aim of this study is to determine the immunologic noninferiority of MenABCWY to licensed vaccines Trumenba and MenACWY-CRM (Menveo) by assessing the safety and immunogenicity of MenABCWY and the comparators in both ACWY-naïve and ACWY-experienced healthy participants ≥10 to <26 years of...
The recent expansion of the hyper-virulent serogroup W strain (cc11) led to an adolescent MenACWY conjugate vaccination program initiated in 2015 for those 14 years of age [86]. Hence, a quadrivalent meningococcal conjugate (ACWY-CRM or ACWY-TT) is administered among these age groups. For tho...
Background In August, 2015, the UK implemented an emergency adolescent immunisation programme with the meningococcal ACWY conjugate vaccine to combat a national outbreak of meningococcal group W (MenW) disease due to a hypervirulent ST-11 complex strain, which is currently causing regional and ...
A, B, C, W and Y strains, percentage of participants whose sera is effective against ≥70% of the strains tested using hSBA at 1 month after different vaccination schedules, and the percentage of patients achieving ≥4-fold rise in hSBA titres from baseline for ACWY and MenB test strains...
no MenB vaccination program exists for this age group in the UK. In France, lockdown measures during COVID-19 were associated with more than 2 years of reduced IMD incidence [21]. However, case numbers in December 2022 exceeded pre-pandemic levels. The majority of cases were MenB (53%)...
Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal car- riage: an observer-blind, phase 3 randomised clinical trial. Lancet. 2014;384(9960):2123-31. doi: 10.1016/S0140-6736(14)60842-4. [PubMed: 25145775]....
Quiambao BP, Jain H, Bavdekar A, Dubey AP, Kolhe D, Bianco V, Van der Wielen M, Miller JM. Persistence of the immune response two years after vaccination with quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in Asian adolescents. Hum Vaccin Immunother 2016; 12:...
Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambiadoi:10.1056/NEJMoa2214924BackgroundAn effective, affordable, multivalent meningococcal conjugate vaccine is needed to prevent epidemic meningitis in the African meningitis belt. Data on the safety and immunogenicity of NmCV-...
Findlow J, Bai X, Findlow H, Newton E, Kaczmarski E, Miller E, Borrow R (2015) Safety and immunogenicity of a four-component meningococcal group B vaccine (4CMenB) and a quadrivalent meningococcal group ACWY conjugate vaccine administered concomitantly in healthy laboratory workers. Vaccine 33...
Several European countries recommend childhood vaccination with vaccines conferring protection against serogroup B, serogroup C and/or serogroups ACWY IMD [11, 12]. Of the five serogroups that cause most disease worldwide (B/A/C/W/Y), serogroup B currently causes most cases of IMD in Europe [...