Meningiomas are slow-growing tumors. Surgery may be suggested based on size and location. "Most meningiomas are benign, and aftersurgery, they may never regrow. Or if they do, it may take a very long time," she says. Glioblastoma Another type of brain tumor is cancerous and fast-growing....
MLN8237, also named as alisertib, is a potent and selective inhibitor targeting AURKA, effectively impeding the phosphorylation and subsequent activation of AURKA. Extensive clinical trials have been carried out to assess its efficacy in various cancer types, and notably, it is the sole AURKA inhibi...
Instituto do Cancer do Estado de São Paulo – Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil Iuri Santana Neville Contributions V.N.Y., G.A.B., L. F. S. G., L.T.L, I.S.N. and W.S.P. contributed to design and implement...
Adjuvant RT is currently the only adjunctive standard-of-care treatment aside from surgery for meningiomas and is generally selected for ‘high-risk’ patients based on WHO grade and/or the presence of residual tumor after surgery. However, response to RT in meningiomas is highly variable, and c...
Cognitive function after radiotherapy for supratentorial low-grade glioma: a north central cancer treatment group prospective study. Int J Radiat Oncol Biol Phys. 2005;63(4):1175–83. doi:10.1016/j.ijrobp.2005.04.016. PubMed PMID: 15964709 Article PubMed Google Scholar Scott JN, Rewcastle ...
It also reviews current clinical studies and novel meningioma treatments, including immunotherapy, microRNAs, cancer stem cell methods, and targeted interventions within the glycolysis pathway. Through the examination of the complex landscape of meningioma biology and the highlighting of promising therape...
As observed in other cancer types, it is possible that non-mutational mechanisms may contribute to NF2 loss of function in a proportion of anaplastic meningiomas19,20. We considered promoter hypermethylation as a source of additional NF2 inactivation, but found no evidence of this (Supplementary ...
Intracranial clear-cell meningioma (CCM) is rarely reported in the literature since it has to be distinguished from other subtypes of meningioma. Most of the CCMs are intraspinal, according to the related literature. We report a case of occipital parietal CCM in a 6-year-old child, review all...
In contrast, the cancer stem cell hypothesis proposes that the cells driving tumor growth are rare and have multipotent potential that manifests through asymmetric divisions. The concept of cancer initiation and progression from primitive embryonal stem cell rests is well established, particularly for ...
Ganswindt U, Paulsen F, Corvin S, Hundt I, Alber M, Frey B, Stenzl A, Bares R, Bamberg M, Belka C: Optimized coverage of high-risk adjuvant lymph node areas in prostate cancer using a sentinel node-based, intensity-modulated radiation therapy technique. Int J Radiat Oncol Biol Phys ...