Multiple pathologies have different genetic, radiographic, clinical and prognostic characteristics in the elderly, responding differently to various treatment modalities and thus present as unique clinical entities, not properly represented in large - guidelines generating studies. We present a two parts ...
The first identified and the most common genetic alteration in meningioma is the inactivation of NF2, which is present in approximately half of sporadic primary meningiomas [14]. To investigate the impact of AURKA on meningioma progression, two malignant meningioma cell lines, namely CH157MN (with...
Credit: Unsplash/CC0 Public Domain Reliably predicting whether meningioma, the most common primary brain tumor, will recur or remain benign has not been easy. In this study, published inScience Advances, researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Inst...
Moreover, attempts to find molecular markers to predict their recurrence have been impeded by low or heterogenous genetic signal. We therefore sought to apply systems-biology approaches to transcriptomic data to better predict meningioma recurrence. We apply gene co-expression networks to a cohort of...
Other brain tumors, such as medulloblastoma and glioma, have been redefined based on molecular and genetic features, allowing for improved prognostication and potential therapeutic targets. "We believed that meningioma might also be amenable to this sort of molecular profiling," said Patel, who also ...
Among those slated to appear are David Carpenter, a coeditor of the BioInitiative Report, Ronald Herberman of the Uni- versity of Pittsburgh Cancer Institute (see July 23, 25 & 28) and the FCC's Julius Knapp, as well as Ellen Marks of California, whose husband is a brain tumor survivor...
The increased emphasis on research dedicated to the study of brain tumors coupled with the advent of new tools in genetic and molecular epidemiology make the current era an ideal time to advance knowledge for intracranial meningioma. This review highlights current knowledge of meningioma epidemiology ...
Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been encumbered by limited understanding of meningioma biology. Here, we use DNA methylation profiling on 565 meningiomas integrated with genetic, transcript...
Finally, the tumor development is not de novo, meaning that xenograft studies are not useful for studying tumor origins. Genetically engineered models (GEM) GEM are based on mice that have undergone genome alterations through various genetic engineering techniques. There are multiple ways of achieving...
Radiation-induced meningioma: a distinct molecular genetic pattern? Radiation-induced meningiomas arise after low-dose irradiation treatment of certain medical conditions and are recognized as clinically separate from spora... Y Shoshan,O Chernova,SS Jeun,... - 《Journal of Neuropathology & Experiment...