“In this proof-of-concept study, we demonstrate that PheWAS could identify SLE disease manifestations in theEHRvalidating PheWAS as a discovery tool,” Barnado said. “Using PheWAS to compare males and females with SLE, we report the first association of i...
Although systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, men may also be affected. Thirty of 261 patients (12%) with SLE seen in this hospital were men. Arthritis was less common as a first symptom in the men, although this group of patients had dis...
Systemic lupus erythematosus (SLE) is a sexually dimorphic autoimmune disease which is more common in women, but affected men often experience a more severe disease. The genetic basis of sexual dimorphism in SLE is not clearly defined. A study was undertaken to examine sex-specific genetic ...
In agreement with other autoimmune diseases, systemic sclerosis (SSc) is associated with a strong sex bias. However, unlike lupus, the effects of sex on di... E Muriel,A Jérme,UA Walker,... - 《Annals of the Rheumatic Diseases》 被引量: 0发表: 2015年 ...
The researchers also don't know what triggers might set off extra VGLL3 activity. But they do know that in men with lupus, the same VGLL3 pathway seen in women with lupus is activated. Many of the current therapies for lupus, like steroids, come with unwanted side effects, from increased...
In agreement with other autoimmune diseases, systemic sclerosis (SSc) is associated with a strong sex bias. However, unlike lupus, the effects of sex on di... E Muriel,A Jérme,UA Walker,... - 《Annals of the Rheumatic Diseases》 被引量: 0发表: 2015年 Gender differences in the clinica...
An international team led by scientists at Stanford University has discovered a probable explanation for a decades-old biological mystery: why vastly more women than men suffer from autoimmune diseases such as lupus and rheumatoid arthritis.Women acc... x chromosome autoimmune disease sex differences ...
(1.5–3.1)), systemic lupus erythematosus (OR = 2.7; 95% CI (1.6–4.6)) or juvenile idiopathic arthritis (OR = 3.5; 95% CI (2.6–4.9)) significantly increased subsequent childlessness in women. Puzzlingly, but consistent with previous findings41, we observed that chronic diseases ...
It turned out that male mice with an active Xist gene developed the lupus-like condition at rates approaching those of females. Because not all female or Xist-activated male mice developed the autoimmune disorder, it shows that some kind of trigger is required to ...
Four out of every five people who live with an autoimmune disease are female. Andwhile men are more likely to die of Covid-19, women have been more likely to develop long Covid, which experts say mimics aspects of autoimmune disorders. ...