However, the incidence of breast cancer in men with the BRCA2 mutation is significantly higher, 7.1% before age 70 (Evans et al., J Med Genet. 2010; 47:710). Due to the low incidence of male breast carcinoma, and even lower incidence of male BRCA2 positive breast cancers, clear ...
Men with an inherited gene mutation may have a higher chance of developing breast cancer. For men with the BRCA2 mutation, for example, the risk of developing breast cancer is about 8 times greater than for men without ...
Up to 25% of patients have a deleterious germline and/or somatic mutation inBRCA1, BRCA2, ATM, or other homologous recombination repair (HRR) gene alterations. Earlier this month, rucaparib received a breakthrough therapy designation from the FDA as a monotherapy for adult patients withBRCA1...
Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary breast cancer The outcome of bilateral prophylactic mastectomy with breast reconstruction (BPM-IBR) in healthy BRCA1/2 mutation carriers can be potentially burdensome fo... JP Go...
There were no significant differences in p53 mutation ( p = 0.20) or erbB -2 oncoprotein overexpression ( p = 0.33) between the men and women studied. Conclusion Survival rates of Japanese male and female breast cancer patients are similar when age and stage of the disease are taken into ...
Prevalence and Penetrance of BRCA1 and BRCA2 Gene Mutations in Unselected Ashkenazi Jewish Women With Breast Cancer BACKGROUND: Approximately 2.0%-2.5% of Ashkenazi Jewish women carry one of three founding mutations in the BRCA1 and BRCA2 genes, and each mutation is asso... E.,Warner,W.,....
Male breast cancer has been linked extensively to mutations of BRCA2 and, to a lesser extent, BRCA1. The aim of this study was to perform a comprehensive analysis of point mutations and genomic rearrangements in the BRCA1 and BRCA2 genes in 41 men with breast cancer. Deleterious point mutat...
CONCLUSIONS: Men with prostate cancer and at least 1 additional primary cancer are enriched for harboring a germline deleterious mutation in a cancer-predisposing gene that may impact cancer prognosis and treatment, but the majority do not meet current criteria for clinical genetic testing. 全文 全文...
Women who have inherited a germ-line mutation in the BRCA1 or BRCA2 (BRCA1/2) genes have a greatly increased risk of developing breast cancer compared with... TR Rebbeck,Y Wang,PW Kantoff,... - 《Cancer Research》 被引量: 744发表: 2001年 PP-4-6 Germline mutation at BRCA1 affects...
Adjuvant Lynparza remains beneficial for patients with BRCA1/2 mutation–positive, HER2-negative high-risk breast cancer, study results have shown. December 12th 2024 Camizestrant Plus Kisqali May Be Safe, Effective in ER+/HER2- Breast Cancer Alex Biese Findings from the phase 1 SERENA-1 st...