Though the chemical gradient can outperform the electrical gradient, the electrical gradient reduces the force driving K+ out of the cell. Equilibrium potential is the membrane potential for an ion when there is no movement of it across the plasma membrane. For potassium, this occurs at a ...
They provided a highly influential quantitative description of the membrane potential changes in terms of changes in the membrane conductances to Na+ and K+, and the relative membrane permeabilities of the membrane to these ions. On the 50th anniversary of the publication of a series of five ...
In the setting of hyperkalaemia, the resting membrane potential is shifted to a less negative value as the concentration gradient driving the movement of K+ ions out of the cell is reduced. So, a normal resting potential value of −70 mV is altered to a less-negative value. This change...
The resting potential is maintained by the sodium-potassium pump, which steadily discharges more positive charge (i.e., Na+) from the cell than it allows in, and by the relatively high permeance of K+, which leaks out of the cell through its membrane channels faster than Na+ leaks in. ...
In line with the notion that increased proton leak is maladaptive for the heart, our study shows that MTFP1 loss in cardiomyocytes reduces the mitochondrial membrane potential as a result of increased proton leak through the IMM (Fig. 2d, e, Fig. S2e–h) preceding the onset of cardiomyopathy...
Théry, C., Ostrowski, M. & Segura, E. Membrane vesicles as conveyors of immune responses.Nat Rev Immunol9, 581–593 (2009). https://doi.org/10.1038/nri2567 Download citation Published05 June 2009 Issue DateAugust 2009 DOIhttps://doi.org/10.1038/nri2567 ...
SE Senogles,AM Spiegel,E Padrell,... - 《Journal of Biological Chemistry》 被引量: 193发表: 1990年 A Position-Specific Distance-Dependent Statistical Potential for Protein Structure and Functional Study Summary Although studied extensively, designing highly accurate protein energy potential is still ...
Vestergaard-Bogind B, Bennekou P (1982) Calcium-induced oscillations in K+ conductance and membrane potential of human erythrocytes mediated by the ionophore A23187. Biochim Biophys Acta 688: 37–44 Article PubMed CAS Google Scholar Vincenzi FF, Hinds TR (1980) Calmodulin and plasma membrane...
This influx of Na+ alters the membrane potential, rendering the inside of the cell electrically positive as it approaches ENa. Because a large amount of Na+ enters the cell during an action potential, the Na+/K+-ATPase pump is required to transport Na+ back out of the cell to maintain ...
The potential of CAR-T cell therapy against cancer prompted a recent effort to use CAR-T cell membranes for drug delivery (Fig. 6B)96. In this study, CAR-T cells were engineered to express single-chain variable fragment, an antibody light chain specific for glypican-3 expressed in ...