The exponential decay of the capacitative charging current was analyzed to give the total membrane capacitance, which was then divided by the observed surface area of the patch. C m was 0.9 渭F/cm 2 for each class of neuron. To test the possibility that membrane proteins may alter C m, ...
Location of the membrane conductance change is possible because the higher-frequency components of the injected currents are progressively attenuated by the axial resistance and membrane capacitance of the neuron as they pass from the injection site to electrotonically more distant regions. For the ...
resistance. The properties of the ion-exchange membrane, the solution, and the electrodes can be described electrically by an equivalent circuit as indicated inFigure 3.11, where Cmand Rmare the membrane capacitance and resistance, respectively, and Rsis the resistance of electrodes and the ...
Fusion of vesicle to the neuronal plasma membrane will decrease the capacitance property of the cell. State True or False. During hyperpolarization, the inside of the neuron's membrane becomes less negative. (a) True (b) False. In case of hyp...
where V is the membrane potential of the neuron, C is the membrane capacitance (1 μF/cm2) and n1-n4 is a rate scaling factor determining the ion channel expression profile in the neuron. IL, IT, Ih1-4, INa, and IK, denote the leak current, low-threshold calcium current, hyperpolari...
Compound fusion, the vesicle-vesicle fusion that forms larger vesicles for subsequent exocytosis (Fig.4c)2, is supported by (1) EM observation of multivesicular-shaped vesicles, vesicles much larger than regular ones, and large vesicular-shape structures at secretory cell PM, (2) capacitance up-...
Calyx of Held A large synapse within the mammalian auditory brainstem that is suitable (in miceand rats) for presynaptic measurement of membrane capacitance and thus for the detection of synaptic vesicle exocytosis and endocytosis on a millisecond timescale. Dendritic spines Small (∼1μm), spine...
where the evolution of areal capacitance is given by C ˙ m = − ε d 2 H H ˙ . Applying a finite difference approximation to the time derivatives of X = H , c ~ , ϕ we simulate the systems evolution by minimising at each time step. For time step n, the Rayleighian is min...
Whole-cell capacitance measurements allow the direct measurement of exocytosis with high temporal resolution. An added benefit of the whole-cell configuration is the possibility to control the cytosolic free calcium concentration allowing examination of the role of intracellular calcium in a variety of pr...
Membrane capacitance C 0.375 nF Time constant: K, AMPA, GABA and NMDA τ1…τ4 80, 2.4, 7 and 100 ms Background opening coefficient: AMPA, GABA and NMDA p1, …, p3 0.875, 0.0625 and 0.0625 a.u. Diffusion coefficient: V, T, K, AMPA, GABA and NMDA w21,…, w26 4, 0, 0.125,...