On December 20, Congress avoided a government shutdown after reaching a short-term deal, called a continuing resolution (CR), to fund the federal government. Included in the agreement was an extension of the National Flood Insurance Program (NFIP). The NFIP will now be funded through March ...
β-transducin repeat-containing protein (β-TrCP), one of the best-characterized substrate recognition components of the SKP1-CUL1-F-box (SCF) E3 ligase, has two distinct paralogs, β-TrCP1 and β-TrCP2, expressed in mammals. Through governing the ubiquitination and degradation of numerous key...
Activation of NLR proteins results in inflammatory responses mediated by NF-kappaB, MAPK, or Caspase-1 activation, accompanied by subsequent secretion of proinflammatory cytokines. Mutations in several members of the NLR protein family have been linked to inflammatory diseases, suggesting these molecules ...
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containing two or three BH regions, belong to the multidomain (or BH1, 2, 3) subgroup, whereas Bad, Bid, Bik/Nbk, Bim/Bod, Blk, Hrk/DP5, Noxa, Puma/Bbc3, Bnip3, Bmf and Bcl-GS (a splice variant of the bcl-g gene) share with each other the nine amino acid BH3 domain (...
DEPARTMENT O F THE NAVY OFFICE OF THE CHIEF OF NAVAL OPERATIONS 2 0 0 0 NAVY PENTAGON WASHINGTON, D.C. 2 0 3 5 0 - 2 0 0 0 OPNAVINST 5350.4D N135 4 Jun 09 OPNAV INSTRUCTION 5350.4D From: Chief of Naval Operations Subj: NAVY ALCOHOL AND DRUG ABUSE PREVENTION AND CONTROL SECNAV...
NeewwDDeelhlhi-i1-11100112255 ADMISSIONNOSTLICIEP Notice is hereby given that an Extra Ordinary General Meeting of the members of the Company will be held as scheduled below: P LEA SE C OMP LET E TH E AD MISSIONDaSyL IP A: ND HFAridNaDy IT OVER AT THE ENTRANCE OF THE MEETING Dat...
The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids m
Jean Marc Rolain1, Bernard La Scola1, Pierre-Edouard Fournier1, Anthony Levasseur1 and Didier Raoult1* Metagenomics revolutionized the understanding of the relations among the human microbiome, health and diseases, but generated a countless number of sequences that have not been assigned to a know...
Introduction Since the discovery of the nuclear factor κB (NF-κB) more than 30 years ago [1] the NF-κB pathway has been the focus of multiple studies owing to its role in the regulation of essential biological processes, such as immune and stress responses, cell survival, or cell ...