英文名称Melflufen hydrochloride 生化机理盐酸美法仑(Melphalan flufenamide)是美法仑的二肽原药,是一种烷化剂。盐酸美法仑对多发性骨髓瘤(MM)细胞具有抗肿瘤活性,并能抑制血管生成。盐酸甲氟脲可诱导多发性骨髓瘤细胞产生抗肿瘤活性,并抑制血管生成。 储存温度2-8°C储存,干燥 ...
MELPHALAN FLUFENAMIDE HYDROCHLORIDE,来源于药化词典-药智数据
Melphalan flufenamide - Oncopeptides Alternative Names: CK-1535; J 1; Mel-flufen; Melphalan flufenamide hydrochloride - Oncopeptides; Melphalan-prodrug-Oncopeptides; Pepaxti; PEPAXTO; Ygalo Latest Information Update: 09 Sep 2024 Price : €55 * Buy Profile Note: Adis is an informat...
Lyophilized preparations of melphalan flufenamideA lyophilized pharmaceutical preparation comprising melphalan flufenamide hydrochloride (J1) and sucrose in which the weight ratio (w / w) between said melphalan flufenamide hydrochloride (J1) and sucrose is 1:25 to 1:75.SPIRA, JACKLEHMANN, FREDRIK...
Melphalan flufenamide, a peptide drug conjugate (PDC), was approved by the FDA during 2021 for the treatment of patients with relapsed or refractory multiple myeloma [160]. Melphalan flufenamide was designed to be a prodrug of melphalan through binding the alkylating agent and target aminopeptidase...
Melflufen (Melphalan flufenamide),Melphalan 的一种二肽前体药物,是一种烷基化剂。Melflufen 对多发性骨髓瘤细胞具有抗肿瘤活性,并抑制血管生成。Melflufen 对骨髓瘤细胞 DNA 不可逆损伤及细胞毒作用。 MelflufenChemical Structure CAS No. :380449-51-4
Melphalan flufenamideCAS:380449-51-4 MW:498.4 MF:C24H30Cl2FN3O3Email Tweet Share Names and ldentifier Computational chemical data Realated Product Infomation1. Names and Identifiers1.1 Name Melphalan flufenamide 1.2 Synonyms CHEMBL4303060; CS-0024709; DTXSID40191461; Ethyl (2S)-2-((2S)-2-amino-...
MELPHALANcas:1465-26-5 Melphalan flufenamidecas:380449-51-4 Melphalan-D8 Hydrochloridecas:1217854-43-7 Melphalan Impurity Bcas:1270153-04-2 Melphalan Impurity 6cas:1951445-22-9 melphalan isopropyl ester hydrochloridecas:757234-98-31. Names and Identifiers 2. Use and Manufacturing 3. Computational ...
FIELD: pharmacology.;SUBSTANCE: weight ratio of melphalan hydrochloride flufenamide (J1) and sucrose is 1:25 to 1:75. The invention also describes a method for preparation of a lyophilized preparation, compositions and kit containing a lyophilized pharmaceutical preparation and their use in treatment ...
MELPHALANcas:1465-26-5 Melphalan flufenamidecas:380449-51-4 Melphalan-D8 Hydrochloridecas:1217854-43-7 Melphalan N-Oxidecas:685847-78-3 Melphalan Impurity 6cas:1951445-22-9 Melphalan Impurity Bcas:1270153-04-21. Names and Identifiers 2. Realated Product Infomation ...