few approaches targeting sleep were applied. Melatonin has been shown to enhance sleep efficiency with virtually no side effects. This study explored melatonin’s benefits for patients with prolonged DoC, as well as the underlying mechanisms involved. ...
Results from a new Cleveland Clinic-led study suggest that melatonin, a hormone that regulates the sleep-wake cycle and is commonly used as an over-the-counter sleep aid, may be a viable treatment option forCOVID-19. As COVID-19 continues to spread throughout the world, particularly with ...
Data are presented as luciferase activity per microgram of protein. 4.8. Statistics Data were obtained from at least three independent experiments. The Student's t-test was used to determine the significance of differences between two groups. Differences with p < 0.01 were regarded as significant ...
Melatonin released in a natural way into the saliva, or added as an external treatment, may have important implications for dental disorders, such as periodontal disease, as well as in the osseointegration of dental implants, due to its anti-inflammatory and osseoconductive effects. Melatonin has...
Melatonin plays a key role in circadian rhythms in the body, but its concentration is also linked to mood fluctuations as well as emotional well-being. In the present study, we present a computational analysis of the binding and activation of melatonin by various P450 isozymes that are known ...
Overall, our results point to the importance of the multicellular context for full MEL activity, especially in a preventive view, and support the use of OCs as a favorable model to explore inflammatory responses. Keywords: organotypic brain slices; hippocampus; microglia; inflammation; melatonin; ...
In recent years, acid rain deposition also considered as a serious abiotic stress that had a harmful effect on agricultural plants [6,7]. It has been observed that acid rain deposition in the plant caused the ultrastructural changes mainly in the mesophyll, chloroplasts, and mitochondria Molecules...