A primary role for melatonin relates to the human circadian system. Endogenous melatonin production is the ideal marker for biological time. Its physiological function in humans probably relates to the fact that low physiological doses of melatonin cause phase advances when administered in the morning...
It sends messages to areas in the brain and body to help control the sleep and wake cycles.When taken as a dietary supplement, its function is to act like the natural sleep hormone. Drowsiness generally occurs within 30 minutes after taking a dose....
The effects of melatonin on physiological function remain unclear, although the therapeutic potential of melatonin is being increasingly recognized. The ai... T Ninomiya,N Iwatani,A Tomoda,... - 《Clinical Physiology》 被引量: 35发表: 2001年 The Secretion and Effects of Melatonin in Humans Altho...
Light can induce an acute suppression and/or circadian phase shift of plasma melatonin levels in subjects with normal color vision. It is not known whether this photic suppression requires an integrated response from all photoreceptors or from a specialized subset of photoreceptors. To determine whethe...
Melatonin in humans.AnimalsHumansPineal GlandMelatoninReceptors, Cell SurfaceSleepReproductionPubertyCircadian RhythmAgingBrzezinski A.doi:10.1056/NEJM199701163360306Brzezinski AN Engl J Med
The function of melatonin, a hormone secreted by the pineal gland primarily at night, has not been definitively established in humans. To determine if pharmacologic doses of melatonin had any behavioral effects it was administered acutely to 14 healthy men. Their mood, performance, memory and visu...
Melatonin in humans. HumansPineal GlandMelatoninReceptors, Cell SurfaceSleepReproductionPubertyCircadian RhythmAgingBrzezinski A.doi:10.1056/NEJM199701163360306Brzezinski A... A Brzezinski - 《N Engl J Med》 被引量: 1724发表: 1997年 Molecular pharmacology, regulation and function of mammalian melatonin rece...
The hormone, melatonin is produced with circadian rhythm by the pineal gland in humans. The melatonin rhythm provides an endogenous synchronizer, modulating e.g. blood pressure, body temperature, cortisol rhythm, sleep-awake-cycle, immune function and anti-oxidative defence. Interestingly, a number ...
However, even though many reports have demonstrated that melatonin has a direct function in inhibiting tumor proliferation, its concentration does not equilibrate outside and inside cells. So there exists an underlying facilitated diffusion or an active process rather than simple passive diffusion. A ...
Melatonin has been demonstrated to differentially alter blood flow to assorted vascular beds by the activation of different melatonin receptors in animal models. The purpose of the present study was to determine the effect of melatonin on blood flow to various vascular beds in humans. Renal (...