Prognosis of stage I melanoma of the skin. Int J Cancer 1980; 26: 733–9Cascinelli N, Morabito A, Bufalino R et al. (WHO collaborating centres for evaluation of methods of diagnosis and treatment of melanoma) (1980) Prognosis of Stage I melanoma of the skin. Int J Cancer 26:733–739...
These proportions did not vary when stratified for melanoma stage. Worse overall survival was seen among patients with multiple primary melanomas compared with patients with a single primary melanoma (hazard ratio, 1.31; 95% CI, 1.20-1.42; P < .001). Conclusions and Relevance A significant...
Serum biomarkers, such as lactate dehydrogenase and S100 β are well established regarding the prognosis and monitoring of melanoma, although their role at stage III resected or metastatic melanoma is not clear [316,317]. Moreover, melanoma-inhibiting activity and vascular endothelial growth factor ...
American Joint Committee on Cancer classification of uveal melanoma (anatomic stage) predicts prognosis in 7,731 patients: the 2013 Zimmerman Lecture Ophthalmology, 122 (2015), pp. 1180-1186 View PDFView articleGoogle Scholar Shields et al., 2012 C.L. Shields, S. Kaliki, M. Furuta, A. Mas...
9and are predictive of melanoma prognosis10. Within the tumor microenvironment, tumor-reactive T lymphocytes play a central role in suppressing tumor growth by infiltrating into malignant lesions and selectively killing cancer cells11,12. However, some subclones of melanoma tumors evade the ...
complexation with other membrane proteins and signal transduction by recruiting the focal adhesion kinase (FAK) or Src family kinases. Thus, integrins can initiate pro-survival but also pro-apoptotic signals. They play an important role at every stage of cancer development, where disturbance in their...
So far, curative treatment is achieved only by surgical resection of primary tumours at an early stage (Balch et al, 2001; Balch et al, 2004). Chemotherapy with the alkylating agents dacarbazine (DTIC) and temozolomide (TMZ) has not shown any effect on median overall survival of patients (...
EClinicalMedicineDabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study(2023) 科研成果奖励 中国黑色素瘤个体化治疗模式的初步建立郭军,孔燕,斯璐,迟志宏,崔传亮,盛锡楠,毛丽丽(2013中...
Melanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40–60% of patients with late-stage disease. Therefore, uncovering the molecular mechanisms behind MBM is necessary to enhance th...
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation Article Open access 20 June 2024 Introduction YAP1 is an oncoprotein and a downstream transcriptional coactivator in the Hippo signaling pathway [1]. YAP1 regulation by the highly conserved Hippo signaling pathw...