Prognosis, Staging, and Reporting of Melanomasdoi:10.1016/B978-0-323-37457-6.00032-8Richard A. ScolyerKlaus J. BusamPathology of Melanocytic Tumors
An accurate and complete pathology report is critical for the optimal management of cutaneous melanoma patients. Protocols for the pathologic reporting of melanoma have been independently developed by the Royal College of Pathologists of Australasia (RCPA), Royal College of Pathologists (United Kingdom)...
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and New Health Pathology, Sydney, Australia Richard A. Scolyer Contributions Study concept (G.V.L.) and study design (A.M.M., R.N.A., M.A.D., J.A.W., C.U.B. and G.V.L.). A.M.M., R.N.A., E.A....
Melanocytes are neural crest-derived cells whose development necessitates extensive migration/invasion to populate the skin and other sites12. This process requires melanoblasts to adopt a migratory phenotype, to interact with and survive in foreign microenvironments, and to colonize distant sites—functi...
13,20-22 Stage at diagnosis was defined according to the American Joint Committee on Cancer (AJCC) staging system.21 Only those patients with adequate pathology information were selected for stage analyses. Patients with melanoma whose tumor sizes were thinner than 1.0 mm with or without ulceratio...
The classification of malignant melanoma, its histological reporting and registration: a revision of the 1972 sydney classification A group of pathologists with an interest in malignant melanoma met in Sydney in 1982 to update the VJ Mcgovern,AJ Cochran,EP Van,... - 《Pathology》...
We were unable to assess the effect of microsatellitosis, as these data are not collected by the NCDB; this factor would, in any case, be expected to be rarely identified in thin lesions and would classify these patients as having stage III disease even before nodal staging. The use of ...
Melanoma pathology reporting and staging. Mod. Pathol. 2020, 33, 15–24. [Google Scholar] [CrossRef] [PubMed] Hessler, M.; Jalilian, E.; Xu, Q.; Reddy, S.; Horton, L.; Elkin, K.; Manwar, R.; Tsoukas, M.; Mehregan, D.; Avanaki, K. Melanoma biomarkers and their potential...
Advances in melanoma research have unveiled critical insights into its genetic and molecular landscape, leading to significant therapeutic innovations. This review explores the intricate interplay between genetic alterations, such as mutations in BRAF, NRAS, and KIT, and melanoma pathogenesis. The MAPK an...
Promoting dormancy of micrometastases, harmonizing surveillance protocols, promoting staging, identifying predictive factors, initiating controlled clinical trials, and standardizing reporting will be critical steppingstones in reaching the final frontier of curing metastatic uveal melanoma....