Resistance to ERK signaling inhibitors in BRAFV600E-mutant melanomas and lung cancers is achieved by parallel convergent mechanisms, including amplification of the mutant allele in extrachromosomal elements, that allow tumors to adapt while maintaining their intratumor heterogeneity. Intermittent treatment wi...
Skin cancers are the most common cancers, and malignant melanoma is the most serious form of skin cancer. Melanoma is the fifth most common cancer in the United States. Signs and symptoms of melanoma Classic warning signs and symptoms of melanoma include any cutaneous lesion that changes color...
The OncLive Melanoma & Skin Cancer condition center page is a comprehensive resource for clinical news and expert insights on various types of skin cancers, including melanoma, basal cell carcinoma, and more. This section features news articles, interviews in written and video format, and podcasts ...
Skin toxicities can persist for more than a year after immune checkpoint inhibitor therapy Cutaneous immune-related adverse events that develop after immune checkpoint inhibitor therapy become chronic in nearly one-quarter of cases, according to a research letter published in JAMA Dermatology. ...
In this review, we focused on summarizing recent research findings of the natural and dietary terpenoids (eucalyptol, eugenol, geraniol, linalool, and ursolic acid) that have anticancer activities for both melanoma and non-melanoma skin cancers. These terpenoids may be helpful to protect skin ...
Melanomais a type ofskin cancer. When it spreads to other places in your body, it's called metastatic, or advanced. You may also hear your doctor refer to it as stage IVmelanoma. Melanoma often spreads to: Tissue under theskin Lymph nodes ...
Cutaneous malignancies affect millions of people worldwide. These cancers cover a wide clinical spectrum, from relatively indolent types, such as the most common form of cancer basal cell carcinoma, to more lethal ones, such as melanoma. In this chapter
Melanoma is the most lethal skin malignancy, driven by genetic and epigenetic alterations in the complex tumour microenvironment. While large-scale molecular profiling of melanoma has identified molecular signatures associated with melanoma progression,
Melanoma skin cancer is only ∼1% of total diagnosed skin cancers, but it causes majority of skin cancer-related deaths due to its high metastatic properties. Incidence of melanoma skin cancer increases in regions closer to the equator, with highest reported rates in Australia/New Zealand and ...
Malignant melanoma is one of the most aggressive cancers responsible for more than 80% of skin cancer-related deaths. Melanoma is a non-epithelial tumour originating in melanocytes, the pigment-producing cells derived from the neural crest (NC). NC is a highly migratory and multipotent cell popul...