OBJECTIVE: The objective was to present a more precise definition of local melanoma recurrence. METHODS: A case is reported and the literature is reviewed. CONCLUSION: Owing to the myriad of different definitions that exist in the medical literature, the term "local melanoma recurrence" is ...
The Society of Immunotherapy for Cancer (SITC) has taken the important first steps in harmonizing and defining irAE terms and clarify the definition of chronic and re-emergent adverse events [12]. A chronic toxicity grading system, identification of toxicity modifiable pathways and risk categories, ...
Staging There are different ways to stage Ocular melanoma. TNM system: which looks at the tumor size (T), whether the cancer has spread into lymph nodes (N) and whether it has spread to other parts (M- metastasised). OM rarely spreads the lymph system, its more likely to spread through...
Definition of response to therapy Response to ICI was classified according to RECIST v1.1 criteria. On the basis of radiographic response, patients were classified as responders (CR, PR or SD) or nonresponders (PD). Clinical endpoints were defined as overall response rate and PFS (defined as t...
One patient reported grade 4 neutropenia and grade 4 thrombocytopenia postdose 1 that fulfilled the definition of an SAE. Ten patients (21.0%) reported a total of 16 SAEs. Two of these SAEs (grade 4 neutropenia and grade 4 thrombocytopenia) reported by one patient were considered by the ...
In defining subjective well-being it is evident that some of the same terminology is used in conceptualizing the broader term of well-being. Confusion continues to exist in this field of research concerning definition of terms as consensus has yet to be reached on the distinctions and boundaries...
End Point Definition and Assessments Overall survival was defined as time from randomization to death from any cause, censoring patients who had not died at the date last known alive. Progression-free survival was defined as time from randomization to disease progression or death (whichever occur...
Cancer cells are by definition heterogeneous. For example, multiple mutational mechanisms may lead to the development of cancer and mutational mechanisms associated with some cancers may differ between one tissue type and another; it is therefore often difficult to predict whether a specific cancer will...
End Point Definition and Assessments Overall survival was defined as time from randomization to death from any cause, censoring patients who had not died at the date last known alive. Progression-free survival was defined as time from randomization to disease progression or death (whichever occurred...
Although the definition and even the existence of the dysplastic nevus are still debated [10,11,23–25], the World Health Organization has set a general consensus for its morphological identification in two primary criteria and, at least, two accompanying minor criteria [26], which are widely ...